883893-69-4Relevant articles and documents
Mild ruthenium-catalyzed intermolecular alkyne cyclotrimerization
Das, Sanjoy K.,Roy, Rene
, p. 4015 - 4018 (1999)
Grubbs' catalyst [(PCy3)2Cl2Ru=CHPh, 7] was shown for the first time to be an effective catalyst for the mild intermolecular cyclotrimerization of terminal alkynes (1-6). The reaction is general and the isomeric trisubstit
Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes
Gawali, Suhas Shahaji,Gunanathan, Chidambaram
, p. 139 - 149 (2019/01/03)
We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2] cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene molecules. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds. Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition. Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst.
Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier
Sagi, Amit,Segal, Ehud,Satchi-Fainaro, Ronit,Shabat, Doron
, p. 3720 - 3727 (2008/02/07)
Self-immolative dendritic prodrugs, activated through a single catalytic reaction by a specific enzyme, could offer significant advantages in inhibition of tumor growth relative to monomeric prodrug, especially if the targeted or secreted enzyme exists at