88442-97-1

Basic information

• Product Name: Benzoic acid, 5-chloro-2-(1H-pyrrol-1-yl)-, methyl ester
• CAS NO: 88442-97-1
• Molecular Formula: C12H10ClNO2
• Molecular Weight: 235.67
• Mol File: 88442-97-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-chloro-2-(1H-pyrrol-1-yl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-chloro-2-(1H-pyrrol-1-yl)-, methyl ester(88442-97-1)
• EPA Substance Registry System: Benzoic acid, 5-chloro-2-(1H-pyrrol-1-yl)-, methyl ester(88442-97-1)

Safety Data

• Hazardous Substances Data: 88442-97-1(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 1604835-38-2 (Z)-N-(tert-butyl)-3-chloro-6-(4-methoxybenzyl)-9-methyl-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide 
• 1604835-37-1 (Z)-N-(tert-butyl)-3-chloro-9-ethyl-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide 
• 1604835-54-2 N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide 
• 1604835-52-0 N-{2-(tert-butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)but-2-ynamide 
• 1604835-51-9 N-{2-(tert-butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)pent-2-ynamide 
• 1604835-50-8 N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-{2-(tert-butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}but-2-ynamide 
• 885056-97-3 5-chloro-2-(1H-pyrrol-1-yl)benzaldehyde 
• 885056-96-2 5-chloro-2-(pyrrol-1-yl)benzyl alcohol 
• 88442-99-3 1-[4-Chloro-2-(hydroxymethyl)phenyl]-2-(hydroxymethyl)pyrrole 
• 866719-51-9 4-chloro-2-(2-formyl-1H-pyrrol-1-yl)benzoic acid 
• 88442-98-2 1-(4-cloro-2-metossicarbonilfenil)pirrolo-2-carbossaldehide 

Relevant articles and documents

Bronsted Acid Catalyzed Cyclization of Inert N-Substituted Pyrroles to Benzo[ f ]pyrrolo[1,2- a ][1,4]diazepines

Two approaches involving intramolecular and intermolecular cyclization, respectively, have been developed for the direct and practical construction of a series of important benzo[ f ]pyrrolo[1,2- a ][1,4]azepines by using Bronsted acid catalysts. Upon catalysis by TsOH, the intramolecular dehydroxylation/ring closure of 3-hydroxy-2-[2-(1 H -pyrrol-1-yl)benzyl]isoindolin-1-ones provided various racemic benzo[ f ]pyrrolo[1,2- a ][1,4]azepines in high yields. Furthermore, enantioenriched benzo[ f ]pyrrolo[1,2- a ][1,4]azepines were also obtained by chiral phosphoric acid catalyzed intermolecular addition of [2-(1 H -pyrrol-1-yl)phenyl]methanamines to 2-formylbenzoates under mild conditions.

Synthesis of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of pyrroles

A new strategy for the synthesis of condensed hetero- or carbocycles such as pyrroloindoles or fluorenes has been developed that involves the Pd-catalyzed cyclization of readily available N-(2-halobenzyl)pyrroles or their phenyl derivatives. The reaction is proposed to proceed via oxidative addition of benzylic halides to Pd(0) followed by base-assisted C-H bond activation. A broad range of condensed cyclic products could be obtained in good to excellent yields under mild conditions. Copyright

Heterocyclic systems. IV

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