885044-06-4Relevant articles and documents
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
Karle, Michael,Knecht, Wolfgang,Xue, Yafeng
, p. 4839 - 4843 (2012/08/13)
In a project to find novel neutral P1 fragments for the synthesis of thrombin inhibitors with improved pharmacokinetic properties, fragments containing a benzothiazole guanidine scaffold were identified as weak thrombin inhibitors. WaterLOGSY (Water-Ligan