885277-48-5Relevant articles and documents
GHRELIN O-ACYLTRANSFERASE INHIBITORS
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Page/Page column 60, (2019/08/26)
This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment
Efficient and fast Heck vinylation of 2-bromo-6-methyl pyridines with methylacrylate. Application to the synthesis of 6-methyl cyclopenta[b]pyridinone
Robert, Nicolas,Hoarau, Christophe,Célanire, Sylvain,Ribéreau, Pierre,Godard, Alain,Quéguiner, Guy,Marsais, Francis
, p. 4569 - 4576 (2007/10/03)
Heck vinylation of 2-bromo-6-methyl-3-substituted pyridines using η3-allylpalladium chloride dimer/P(o-Tol)3 complex/toluene and dimethylacetamide (DMA) as co-solvent with methyl acrylate is reported. Electronic and steric effects were investigated engaging diversely 2-bromo-3,6-disubstituted pyridines. As application, a new synthesis of the 6-methyl cyclopenta[b]pyridinone building-block connecting Heck vinylation, alkene reduction and Dieckmann condensation is described.