88621-01-6

Basic information

• Product Name: CefixiMe Methyl Ester
• Synonyms: CefixiMe Methyl Ester
• CAS NO: 88621-01-6
• Molecular Formula: C₁₇H₁₇N₅O₇S₂
• Molecular Weight: 467.47618
• Product Categories: Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 88621-01-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.73±0.1 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 2.79±0.50(Predicted)
• CAS DataBase Reference: CefixiMe Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: CefixiMe Methyl Ester(88621-01-6)
• EPA Substance Registry System: CefixiMe Methyl Ester(88621-01-6)

Safety Data

• Hazardous Substances Data: 88621-01-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 88621-01-6 differently. You can refer to the following data:
1. Cefixime Methyl Ester is an ester impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).
2. Cefixime Methyl Ester is an intermediate in the synthesis of Cefixime (C242800), an orally active, third generation cephalosporin antibiotic.

Upstream product

• 17356-08-0 thiourea 
• 79349-82-9 (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 80544-17-8 2-(2-aminothiazol-4-yl)-2-[(Z)-methoxycarbonylmethoxyimino]acetic acid 

Downstream Products

• 79350-37-1 cefixime 

Relevant articles and documents

Method of synthesizing cefixime

The invention discloses a method for synthesizing cefixime. The method comprises the following steps: (1) carrying out an amidation reaction between MICA ((Z)-2-(methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid) sulfur-phosphorous active ester and 7-AVCA to obtain cefixime methyl ester, wherein the structure of the MICA sulfur-phosphorous active ester is as shown in the formula (II); (2) hydrolyzing the cefixime methyl ester to obtain cefixime. According to the synthesizing method, a new MICA active ester, namely (z)-2-(2-amino-4-thiazolyl)-methoxycarbonyl methylene imino-acetic acid-diethyl phosphoryl active ester, is adopted, a byproduct diethyl phosphate has small toxicity; and the diethyl phosphate is liquid and can be easily removed, the method is simple in steps and is high in yield.

Process for purification of a cephalosporin derivative

A process for the purification of cefixime via a novel tert.octylamine salt of a cefixime intermediate which may be crystalline and which may be produced in a one pot reaction from 7-amino-3-vinyl-ceph-3-em-4-carboxylic acid.