886362-73-8 Usage
General Description
4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE is an organic compound that belongs to the class of quinoline derivatives. It is a yellow crystalline solid with a molecular formula C10H4ClFN2. This chemical is commonly used as an intermediate in the synthesis of pharmaceutical drugs, agrochemicals, and other fine chemicals. It is also used in the preparation of various heterocyclic compounds and has potential applications in medicinal chemistry and drug development. The compound's unique structure and reactivity make it a valuable building block for the production of diverse chemical substances.
Check Digit Verification of cas no
The CAS Registry Mumber 886362-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,6 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 886362-73:
(8*8)+(7*8)+(6*6)+(5*3)+(4*6)+(3*2)+(2*7)+(1*3)=218
218 % 10 = 8
So 886362-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H4ClFN2/c11-10-6(4-13)5-14-9-2-1-7(12)3-8(9)10/h1-3,5H
886362-73-8Relevant articles and documents
Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu7Positive Allosteric Modulator Tool Compound
Reed, Carson W.,Kalbfleisch, Jacob J.,Wong, Madison J.,Washecheck, Jordan P.,Hunter, Ashton,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.
, p. 1773 - 1779 (2020/10/19)
Herein, we report the discovery of the first selective and CNS penetrant mGlu7 PAM (VU6027459) derived from a "molecular switch"within a selective mGlu7 NAM chemotype. VU6027459 displayed CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78), it was orally bioavailable in rats (%F = 69.5), and undesired activity at DAT was ablated.
