889675-07-4

Basic information

• Product Name: 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole
• Synonyms: 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole
• CAS NO: 889675-07-4
• Molecular Weight: 341.453
• Mol File: 889675-07-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole(889675-07-4)
• EPA Substance Registry System: 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole(889675-07-4)

Safety Data

• Hazardous Substances Data: 889675-07-4(Hazardous Substances Data)

Upstream product

• 79315-62-1 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole 
• 100-39-0 benzyl bromide 
• 20289-26-3 4-benzyloxy-1H-indole 
• 2380-94-1 1H-indol-4-ol 
• 889675-05-2 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone 
• 889675-06-3 1-(4-(benzyloxy)-1H-indol-2-yl)ethanol 
• 39843-70-4 4-(benzyloxy)-2-ethyl-1H-indole 

Downstream Products

• 172732-68-2 ((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid 
• 889675-08-5 tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 
• 220862-18-0 tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 
• 172733-06-1 1-benzyl-2-ethyl-1H-indol-4-ol 

Relevant articles and documents

The first potent inhibitor of mammalian group X secreted phospholipase A2: Elucidation of sites for enhanced binding

Using the X-ray structure of human group X secreted phospholipase A 2 (hGX), we carried out structure-based design of indole-based inhibitors and prepared the compounds using a new synthetic route. The most potent compound inhibited hGX and the mouse orthologue with an IC50 of 75 nM. This compound is the most potent hGX inhibitor reported to date and was also found to inhibit a subset of the other mouse and human SPLA 2S.