889943-46-8

Basic information

• Product Name: 2-Ethoxybenzimidohydrazide
• Synonyms: 2-Ethoxybenzimidohydrazide
• CAS NO: 889943-46-8
• Molecular Weight: 179.222
• Mol File: 889943-46-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Ethoxybenzimidohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxybenzimidohydrazide(889943-46-8)
• EPA Substance Registry System: 2-Ethoxybenzimidohydrazide(889943-46-8)

Safety Data

• Hazardous Substances Data: 889943-46-8(Hazardous Substances Data)

Usage

Description

2-Ethoxybenzimidohydrazide, also known as N-(2-Ethoxyphenyl)benzene-1,2-diamine, is a chemical compound with the molecular formula C9H12N2O. It is a white to off-white powder that is commonly used as a reagent in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical and Agrochemical Production:
2-Ethoxybenzimidohydrazide is used as an intermediate in the production of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used in Industrial Chemical Production:
2-Ethoxybenzimidohydrazide is also used in the production of various industrial chemicals, highlighting its versatility in different chemical processes.
Used as a Corrosion Inhibitor:
2-Ethoxybenzimidohydrazide serves as a corrosion inhibitor, protecting materials from degradation and extending their lifespan in various industrial applications.
Used as a Stabilizer in Plastic Production:
In the plastics industry, 2-Ethoxybenzimidohydrazide is utilized as a stabilizer to enhance the durability and performance of plastic products.
Used in Antimicrobial and Anti-Fungal Applications:
Due to its antimicrobial and antifungal properties, 2-Ethoxybenzimidohydrazide is employed in a variety of industrial and agricultural applications to prevent the growth of harmful microorganisms and fungi.

Upstream product

• 53623-81-7 2-Ethoxybenzamidine 
• 6609-57-0 2-ethoxybenzonitrile 
• 18637-00-8 2-ethoxy-benzamidine hydrochloride 

Downstream Products

• 224789-25-7 4-ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride 
• 224789-20-2 2-(2-Ethoxyphenyl)-5,7-dimethyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 1417529-52-2 3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one 
• 1255919-01-7 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one 
• 1393652-32-8 2-(2-ethoxyphenyl)-5-methyl-7-phenyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one 
• 1259288-29-3 N-(2-{4-[5-(2-ethoxyphenyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]phenoxy}ethyl)-N-methylpyridin-2-amine 
• 224789-21-3 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 927690-90-2 N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide 

Relevant articles and documents

Synthetic method of vardenafil hydrochloride impurities

The invention discloses a synthetic method of vardenafil hydrochloride impurities, which relates to the technical field of pharmaceutical and chemical industry. The synthetic method comprises the following steps: taking alanine (A) as a raw material to react with acetic anhydride, generating 2-acetaminopropionic acid (B), enabling the 2-acetaminopropionic acid (B) to react with ethyl oxalyl monochloride, and generating a reaction product (C); enabling 2-ethoxybenzamidine hydrochloride (D) to react with hydrazine hydrate, generating a reaction product (E), enabling the reaction product (E) to react with the reaction product (C), and generating an impurity intermediate I (F); and enabling the impurity intermediate I (F) to generate an impurity intermediate II (G) under the effect of phosphorus oxychloride; performing sulfonation reaction on the impurity intermediate II (G) to generate a reaction product (H); and dropwise adding N-ethylpiperazine into the reaction product (H) to obtain a target product (I) 4-ethoxy-3-(3,4-dihydro-5-methyl-4-oxo-7-propylimidazole[5,1-f][1,2,4]-trizone-ketone) benzenesulfonic acid. The method is low in production cost, low in requirement on reaction conditions, favorable for the industrialized production and higher in purity of target products.

Alternative method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)- one - A substrate for the preparation of phosphodiesterase (5) inhibitors

Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, as isosteres of purine, are of interest for pharmaceutical research as potential substrates for the synthesis of cGMP-PDE5 inhibitors. We present a novel, alternative method for the synthesis of imidazotriazinones, that differs from the previously reported ones with respect to the method of construction of the triazinone ring in the molecule. The key step in our approach is condensation of an appropriate α-keto-ester with amidrazones, leading to the triazinone heterocycle. Several different substituted imidazolotriazinones have been synthesized in this manner.

Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors

2-Aryl-substituted imidazo[5,1-f][1,2,4]triazin-4(3H)-ones represent a new class of potent cGMP-PDE 5 inhibitors that prove to be superior to other purine-isosteric inhibitors. Subnanomolar inhibitors of PDE 5 with activity in in vivo models for erectile dysfunction have been identified. BAY 38-9456 (Vardenafil-hydrochloride) has been selected for clinical studies in the indication of erectile dysfunction.