89076-64-2

Basic information

• Product Name: 5-NITRO-2-PHENYLPYRIDINE
• Synonyms: 5-NITRO-2-PHENYLPYRIDINE;5-NITRO-2-METHYLANISOLE;(5-Nitropyridin-2-yl)benzene;3-Nitro-6-phenylpridine
• CAS NO: 89076-64-2
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 89076-64-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 116-118°
• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.252 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-NITRO-2-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)
• EPA Substance Registry System: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89076-64-2(Hazardous Substances Data)

Usage

General Description

5-Nitro-2-phenylpyridine is a chemical compound with the molecular formula C11H8N2O2. It is a nitroaromatic compound that contains a pyridine ring and a phenyl group. 5-NITRO-2-PHENYLPYRIDINE is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other functional materials. It is also used as a reagent in chemical reactions to introduce the 5-nitro-2-phenylpyridine moiety into target molecules. The nitro group in this compound makes it reactive and allows it to participate in various chemical reactions like nitration, reduction, and coupling reactions, making it an important intermediate in the synthesis of various organic compounds.

Upstream product

• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 98-86-2 acetophenone 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 98-80-6 phenylboronic acid 
• 4487-59-6 2-bromo-5-nitropyridine 
• 108-86-1 bromobenzene 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 603-33-8 triphenylbismuthane 
• 100-58-3 phenylmagnesium bromide 
• 30651-24-2 5-nitropicolinic acid 
• 71-43-2 benzene 
• 4747-13-1 α-methoxystyrene 
• 3433-56-5 1-(1-phenylvinyl)pyrrolidine 

Downstream Products

• 849353-27-1 (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester 
• 1332586-73-8 N-(6-phenylpyridin-3-yl)-4-sulfamoylbenzamide 
• 1332586-74-9 4-cyano-N-(6-phenylpyridin-3-yl)benzamide 
• 1344663-90-6 3-nitro-6-phenyl-2-p-tolylpyridine-1-oxide 
• 1344663-91-7 3-nitro-2-isopropyl-6-phenylpyridine-1-oxide 
• 1344663-92-8 2-cyclohexyl-3-nitro-6-phenylpyridine-1-oxide 
• 1344663-50-8 2-phenyl-5-nitropyridine N-oxide 
• 1357166-19-8 2-(5-nitropyridine-2-yl)phenol 
• 1357165-44-6 C₁₁H₈N₃⁽¹⁺⁾*Cl^(1-) 
• 1357164-10-3 4-amino-3-(6-phenylpyridine-3-ylazo)naphthalene-1-sulfonic acid sodium salt 
• 1335110-50-3 5-nitro-2,4-diphenylpyridine 
• 126370-67-0 6-phenylpyridin-3-amine 

Relevant articles and documents

Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis

Selective chemistry that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp3)-H bond in the methyl group of N6-methyl deoxyadenosine and N6-methyl adenosine, epigenetic modifications of emerging importance. A carefully orchestrated reaction combines reduction of a nitropyridine to form a nitrosopyridine spin-trapping reagent and an exquisitely selective tertiary amine-mediated hydrogen-atom abstraction at the N6-methyl group to form an α-amino radical. Cross-coupling of the putative α-amino radical with nitrosopyridine leads to a stable conjugate, installing a label at N6-methyl-adenosine. We show that N6-methyl deoxyadenosine-containing oligonucleotides can be enriched from complex mixtures, paving the way for applications to identify this modification in genomic DNA and RNA.

METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine

The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (3) are reported. The electron-deficient nature of 3 permits rapid cycloaddition with a variety of electron-rich dienophiles, including amidines, enamines, enol ethers, ynamines, and ketene acetals in high to moderate yields. 1H NMR studies of a representative cycloaddition reaction between 3 and an amidine revealed a remarkable reaction rate and efficiency (1 mM, 3CN, 23 °C, >95%).