892495-24-8Relevant articles and documents
Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents
Cheng, Xian-Chao,Liu, Xin-Yong,Xu, Wen-Fang,Guo, Xiu-Li,Zhang, Ning,Song, Yu-Ning
experimental part, p. 3018 - 3024 (2009/09/05)
A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound E1 was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed.