94747-49-6

Basic information

• Product Name: 1-(4-METHOXYBENZOYL)-PIPERAZINE
• Synonyms: CHEMBRDG-BB 4004081;1-(4-METHOXYBENZOYL)-PIPERAZINE;(4-METHOXYPHENYL)(PIPERAZIN-1-YL) METHANONE;1-(4-methoxybenzoyl)piperazine hydrochloride;1-(4-methoxybenzoyl)piperazine(SALTDATA: CF3COOH);1-(4-methoxybenzoyl)piperazine CF3COOH;1-(4-Methoxybenzoyl)-piperazi
• CAS NO: 94747-49-6
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Product Categories: piperazines
• Mol File: 94747-49-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 140°C
• Flash Point: 192.3 °C
• Appearance: /
• Density: 1.132 g/cm³
• Vapor Pressure: 1.99E-06mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-(4-METHOXYBENZOYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYBENZOYL)-PIPERAZINE(94747-49-6)
• EPA Substance Registry System: 1-(4-METHOXYBENZOYL)-PIPERAZINE(94747-49-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 94747-49-6(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxybenzoyl)-piperazine, also known as 4-methoxybenzoylpiperazine or MBZP, is a chemical compound that belongs to the piperazine class of compounds. It is a psychoactive drug and a derivative of the illegal drug, benzylpiperazine (BZP). MBZP acts as a stimulant and is often used as a party drug or recreational drug due to its ability to produce feelings of euphoria, increased energy, and alertness. It can also cause side effects such as increased heart rate, high blood pressure, and insomnia. Due to its psychoactive properties, MBZP is classified as a controlled substance in many countries and is illegal to manufacture, distribute, or possess without proper authorization.

InChI:InChI=1/C12H16N2O2/c1-16-11-4-2-10(3-5-11)12(15)14-8-6-13-7-9-14/h2-5,13H,6-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 24642-86-2 2,4-dinitrophenyl 4-methoxybenzoate 
• 4231-69-0 1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole 
• 100-07-2 4-methoxy-benzoyl chloride 
• 77750-05-1 4-methoxy-thiobenzoic acid S-(4-nitro-phenyl ester) 
• 100-09-4 4-methoxybenzoic acid 
• 7464-46-2 p-nitrophenyl p-methoxybenzoate 

Downstream Products

• 1075247-97-0 C₂₃H₂₄N₂O₅ 
• 892495-24-8 2-[4-(4-methoxybenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 1622867-18-8 C₂₆H₂₄N₄O₄S 
• 1099242-60-0 (4-methoxyphenyl)(4-(2-(4-chlorophenoxy)ethyl)piperazin-1-yl)methanone 

Relevant articles and documents

Novel imidazopyrimidines-based molecules induce tetramerization of tumor pyruvate kinase M2 and exhibit potent antiproliferative profile

Discovery of novel and potent lead molecules for the specific therapeutic targets by de novo drug design is still in infancy. Here, we disclose the unprecedented development of imidazopyri(mi)dine-based tumor pyruvate kinase M2 (PKM2) modulators by subseq

N-Acylbenzotriazole: convenient approach for protecting group-free monoacylation of symmetric diamines

Abstract: An efficient green route for monoacylation of aromatic diamines, namely o-phenylenediamine and p-phenylenediamine and aliphatic diamines ethylenediamine and piperazine using N-acylbenzotriazoles (NABs) in n-butanol was developed. The new protocol does not require prior selective protection of the diamine and comprises simple conditions, short reaction times, an easy work up as well as high isolated yields (69–94%). Moreover, the method described herein enable stepwise acylation of aliphatic diamines such as ethylenediamine and piperazine with two different N-acylbenzotriazoles affording unsymmetrical substituted diamines that can be used for construction of pharmaceutically important targets such as drugs, foldamers, and drug conjugates. Graphic abstract: [Figure not available: see fulltext.]

Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents

Using matrine (1) as the lead compound, a series of new piperazinyl matrine derivatives were designed, synthesized and evaluated for their antitumor activities in vitro and in vivo. Structure activity relationship (SAR) analysis indicated that introductio