89607-23-8Relevant articles and documents
Synthesis of ureas in the bio-alternative solvent Cyrene
Mistry, Liam,Mapesa, Kopano,Bousfield, Thomas W.,Camp, Jason E.
supporting information, p. 2123 - 2128 (2017/07/24)
Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as
Gold(I)-catalyzed intramolecular hydroamination of N-allylic N′-arylureas to form imidazolidin-2-ones
Li, Hao,Song, Feijie,Widenhoefer, Ross A.
supporting information; experimental part, p. 955 - 962 (2011/06/25)
Treatment of N-allylic N′-arylureas with a catalytic 1:1 mixture of di-tert-butyl-o-biphenylphoshphine gold(I) chloride and silver hexafluorophosphate (1 mol%) in chloroform at room temperature led to 5-exo-hydroamination to form the corresponding imidazolidin-2-ones in excellent yield. In the case of N-allylic ureas that possessed an allylic alkyl, benzyloxymethyl, or acetoxymethyl substituent, gold(I)-catalyzed 5-exo-hydroamination leads to formation of the corresponding trans-3,4-disubstituted imidazolidin-2-ones in excellent yield with ≥50:1 diastereoselectivity.
A new synthesis of imidazolidin-2-ones via Pd-catalyzed carboamination of N-allylureas
Fritz, Jonathan A.,Nakhla, Josephine S.,Wolfe, John P.
, p. 2531 - 2534 (2007/10/03)
A new strategy for the preparation of substituted imidazolidin-2-ones in two steps from readily available N-allylamines is described. Addition of the amine starting materials to isocyanates affords N-allylureas, which are converted to imidazolidin-2-one p