896722-51-3 Usage
Description
1-(Phenylsulphonyl)-6-Methyl-7-azaindole is a heterocyclic chemical compound that belongs to the class of indole derivatives. It features a sulfonyl group and a methyl group attached to the indole ring, which contributes to its unique chemical properties and potential applications.
Used in Pharmaceutical Industry:
1-(Phenylsulphonyl)-6-Methyl-7-azaindole is used as a pharmaceutical intermediate for the development of various biologically active compounds. Its indole core and sulfonyl group provide a versatile structure that can be further modified to create new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
1-(Phenylsulphonyl)-6-Methyl-7-azaindole is used as an agrochemical intermediate for the synthesis of compounds with pesticidal or herbicidal properties. 1-(Phenylsulphonyl)-6-Methyl-7-azaindole's structure can be tailored to target specific pests or weeds, offering a new avenue for the development of effective and environmentally friendly agrochemicals.
Used in Synthetic Chemistry:
1-(Phenylsulphonyl)-6-Methyl-7-azaindole is used as a building block in the synthesis of various valuable compounds. Its sulfonyl group provides unique reactivity, allowing for the creation of a wide range of chemical products with diverse applications in research, industry, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 896722-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,6,7,2 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 896722-51:
(8*8)+(7*9)+(6*6)+(5*7)+(4*2)+(3*2)+(2*5)+(1*1)=223
223 % 10 = 3
So 896722-51-3 is a valid CAS Registry Number.
896722-51-3Relevant articles and documents
Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors
Liu, Bin,Yuan, Xia,Xu, Bo,Zhang, Han,Li, Ridong,Wang, Xin,Ge, Zemei,Li, Runtao
, p. 1 - 15 (2019/03/17)
Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 was systematically optimized. The results showed that compound 6f, which has a difluoroethyl substitution on the 7-azaindole ring, exhibited high PKM2 activation potency and anti-proliferation activities on A375 cell lines. In a xenograft mouse model, oral administration of compound 6f led to significant tumor regression without obvious toxicity. Further mechanistic studies revealed that 6f could influence the translocation of PKM2 into nucleus, as well as induction of apoptosis and autophagy of A375 cells. More importantly, compound 6f significantly inhibited migration of A375 cells in a concentration-dependent manner. Collectively, 6f may serve as a lead compound in the development of potent PKM2 activators for cancer therapy.
Anti-tumor compounds
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Page/Page column 11, (2008/06/13)
Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and ---- are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder w
