89854-70-6

Basic information

• Product Name: 1-Methyl-cyclohexylamine hydrochloride
• Synonyms: 1-Methyl-cyclohexylamine hydrochloride;1-Amino-1-methylcyclohexane hydrochloride;1-Amino-1-methylcyclohexane hydrochloride 95%;1-Methyl-1-aminocyclohexane hydrochloride;1-methyl-1-cyclohexanamine hydrochloride;1-methylcyclohexan-1-amine hydrochloride;Cyclohexylamine, 1-methyl-, hydrochloride;1-Methylcyclohexanamine hydrochloride
• CAS NO: 89854-70-6
• Molecular Formula: C₇H₁₅N*ClH
• Molecular Weight: 149.67
• Mol File: 89854-70-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 178-183°C
• Boiling Point: 148.3°Cat760mmHg
• Flash Point: 27.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 4.26mmHg at 25°C
• CAS DataBase Reference: 1-Methyl-cyclohexylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-cyclohexylamine hydrochloride(89854-70-6)
• EPA Substance Registry System: 1-Methyl-cyclohexylamine hydrochloride(89854-70-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: GX1535000
• Hazardous Substances Data: 89854-70-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-cyclohexylamine hydrochloride is a chemical compound that consists of a cyclohexane ring with a methyl group and an amine group attached to it. It is in the form of a hydrochloride salt, which is a common way of making a compound more stable and easier to handle. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of rubber accelerators, antioxidants, and corrosion inhibitors. Additionally, 1-Methyl-cyclohexylamine hydrochloride can be used as a solvent or reagent in chemical reactions. 1-Methyl-cyclohexylamine hydrochloride's strong odour makes it unsuitable for use in food or cosmetic products but it has numerous industrial applications.

InChI:InChI=1/C7H15N.ClH/c1-7(8)5-3-2-4-6-7;/h2-6,8H2,1H3;1H

Upstream product

• 22530-83-2 1-azido-1-methylcyclohexane 
• 1133989-31-7 N-(1-methylcyclohexyl)-tert-butanesulfinamide 
• 82166-21-0 methyl cyclohexane 
• 931-78-2 1-chloro-1-methylcyclohexane 

Downstream Products

• 1578244-44-6 N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-(1-methylcyclohexyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 940305-34-0 3-(2-chloro-4-{[5-(2-hydroxyethyl)-5H-pyrrolo[3,2-d]pyrimidin-4-yl]amino}phenoxy)-N-(1-methylcyclohexyl)benzamide 

Relevant articles and documents

One-Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp3 C?H Imination

The direct replacement of sp3 C?H bonds with simple amine units (?NH2) remains synthetically challenging, although primary aliphatic amines are ubiquitous in medicinal chemistry and natural product synthesis. We report a mild and selective protocol for preparing primary and secondary aliphatic amines in a single pot, based on intermolecular sp3 C?H imination. The first C?H imination of diverse alkanes, this method shows useful site-selectivity within substrates bearing multiple sp3 C?H bonds. Furthermore, this reaction tolerates polar functional groups relevant for complex molecule synthesis, highlighted in the synthesis of amine pharmaceuticals and amination of natural products. We characterize a unique C?H imination mechanism based on radical rebound to an iminyl radical, supported by kinetic isotope effects, stereoablation, resubmission, and computational modeling. This work constitutes a selective method for complex amine synthesis and a new mechanistic platform for C?H amination.

DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS

The invention provides compounds of formula (I), the prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein wherein R is as defined herein; pharmaceutical compositions thereof;