89977-05-9Relevant articles and documents
One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation
Deng, Daniel Da,Dong, Weitong,Fu, Yan,Jin, Xiangle,Xing, Lidong,Yan, Jun
, p. 1541 - 1544 (2022/02/07)
This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent of the Guareschi-Thorpe Condensation.