65169-64-4

Basic information

• Product Name: 4-Pyridinecarboxylic acid, 2-amino-6-methyl-
• Synonyms: 4-Pyridinecarboxylic acid, 2-amino-6-methyl-;2-AMino-6-Methylisonicoti...;2-AMino-6-Methylisonicotinic acid;2-amino-6-methylpyridine-4-carboxylic acid
• CAS NO: 65169-64-4
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Mol File: 65169-64-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 455.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.337±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.18±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridinecarboxylic acid, 2-amino-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylic acid, 2-amino-6-methyl-(65169-64-4)
• EPA Substance Registry System: 4-Pyridinecarboxylic acid, 2-amino-6-methyl-(65169-64-4)

Safety Data

• Hazardous Substances Data: 65169-64-4(Hazardous Substances Data)

Usage

Uses

2-Amino-6-methylisonicotinic Acid can be prepared to use as T-type calcium channel blockers to treat pruritus.

Upstream product

• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 91558-58-6 diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate 
• 89977-05-9 2-amino-6-methylpyridine-3,4-dicarboxylic acid 
• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 

Downstream Products

• 1029128-50-4 2-amino-6-methyl-isonicotinic acid methyl ester 
• 1372127-17-7 C₁₈H₁₄O₈*C₂₇H₃₄ClN₅O₃ 
• 1251528-23-0 C₂₇H₃₄ClN₅O₃ 
• 1251527-64-6 C₂₆H₃₁ClN₄O₄ 

Relevant articles and documents

One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation

This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent of the Guareschi-Thorpe Condensation.

CO-CRYSTALS AND SALTS OF CCR3-INHIBITORS

This invention relates to co-crystals and salts of CCR3 inhibitors of formula (1), pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS

Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.