90484-46-1Relevant articles and documents
alpha-halogenated unsaturated aldehyde ketone preparation method
-
Paragraph 0042-0046, (2019/11/29)
The invention relates to an alpha-halogenated unsaturated aldehyde ketone preparation method, which comprises: mixing a propargyl alcohol derivative, a halogen source, an acid and a solvent, and carrying out a heating reaction to obtain the alpha-halogena
Catalyst-Free Halogenation of α-Diazocarbonyl Compounds with N-Halosuccinimides: Synthesis of 3-Halooxindoles or Vinyl Halides
Ma, Chaoqun,Xing, Dong,Hu, Wenhao
supporting information, p. 3134 - 3137 (2016/07/13)
A novel catalyst-free halogenative cyclization of N-aryl diazoamides with N-halosuccinimides (NXS) is reported for the synthesis of 3-halooxindoles through a carbene-free mechanism. N-Aryl diazoamides reacted with NXS under mild and catalyst-free conditio
Preparation of α-haloacrylate derivatives via dimethyl sulfoxide-mediated selective dehydrohalogenation
Li, Wei,Li, Jianchang,Wan, Zhao-Kui,Wu, Junjun,Massefski, Walter
, p. 4607 - 4610 (2008/03/13)
(Chemical Equation Presented) Dimethyl sulfoxide causes α/β-dihalopropanoate derivatives to undergo efficient, selective dehydrohalogenation to form α-haloacrylate analogues. A variety of α-halo Michael acceptors were prepared in dimethyl sulfoxide under mild, base-free conditions, including the preparation of α-bromoacrolein and α-chloro- and bromoacrylonitriles. Synthesis of these molecules has been reported in the literature to be difficult. Among all the existing dehydrohalogenation procedures, this protocol is the most facile, practical, and environmentally benign process.