905580-90-7Relevant articles and documents
Tumor inhibitor MLN4924 synthetic method (by machine translation)
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Paragraph 0039; 0042, (2017/07/22)
The invention discloses tumor inhibitor MLN4924 synthetic method, which belongs to the field of chemical synthesis, the method to compound A and compound E as the starting material, by mitsunobu reaction, amination reaction, deprotected base and sulphur esterification four-step reaction can synthesize the target product MLN4924, has the advantage of short synthetic route, and the raw material source is wide, low cost, mild reaction conditions, the operation is safe, friendly to the environment, high yield, can be up to 40% more than, is suitable for industrial large-scale production. (by machine translation)
HYDROCHLORIDE SALT OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO [2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE
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Page/Page column 36, (2010/12/17)
Disclosed is a compound of formula (I); crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an El activating enzyme, particularly NAE, including, e.g., cancer.
INHIBITORS OF E1 ACTIVATING ENZYMES
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Page/Page column 138, (2008/06/13)
This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.