9082-71-7

Basic information

• Product Name: EC 1.4.1.9
• Synonyms: L-LEUDH;L-LEUCINE DEHYDROGENASE;L-LEUCINE DEHYDROGENASE, BACILLUS CEREUS;L-LEUCINE:NAD+-OXIDOREDUCTASE;L-LEUCINE: NAD+ OXIDOREDUCTASE [DEAMINATING];EC 1.4.1.9;EC: 1.4.1.9;LEUCINE DEHYDROGENASE
• CAS NO: 9082-71-7
• Molecular Weight: 0
• Product Categories: Oxidoreductases;Specialty Enzymes
• Mol File: 9082-71-7.mol
• Article Data: 0

Chemical Properties

• Appearance: slightly brown/solution
• Storage Temp.: −20°C
• CAS DataBase Reference: EC 1.4.1.9(CAS DataBase Reference)
• NIST Chemistry Reference: EC 1.4.1.9(9082-71-7)
• EPA Substance Registry System: EC 1.4.1.9(9082-71-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 9082-71-7(Hazardous Substances Data)

Usage

Description

EC 1.4.1.9, also known as L-Leucine Dehydrogenase, is a member of the amino acid dehydrogenase family. It is an enzyme that catalyzes the conversion of L-leucine to alpha-ketoisocaproate, with the concomitant reduction of NAD+ to NADH. This enzyme plays a crucial role in the reversible oxidation of L-leucine and is involved in the catabolism of branched-chain amino acids.

Uses

Used in Clinical Diagnostics:
EC 1.4.1.9 is used as a diagnostic tool for determining the levels of branched-chain amino acids (BCAA) in serum samples. This is particularly important for monitoring patients with various medical conditions, such as liver disease, muscle disorders, and inborn errors of metabolism, where BCAA levels can be significantly altered.
Used in Research:
L-Leucine Dehydrogenase is also used in research settings to study the metabolism of branched-chain amino acids and their role in various physiological processes. This enzyme can be employed in biochemical assays and as a research tool for investigating the mechanisms of amino acid catabolism and the regulation of BCAA levels in different organisms.
Used in Pharmaceutical Development:
The enzyme L-Leucine Dehydrogenase can be utilized in the development of new drugs and therapies targeting the metabolism of branched-chain amino acids. By understanding the role of this enzyme in the catabolism of BCAA, researchers can potentially develop treatments for conditions related to amino acid imbalances or deficiencies.
Used in Food Industry:
L-Leucine Dehydrogenase can be employed in the food industry for the production of specific amino acids or other related compounds. This enzyme can be used in fermentation processes to enhance the production of L-leucine or other branched-chain amino acids, which are essential for various food products and supplements.

Biochem/physiol Actions

Leucine Dehydrogenase is a nicotinamide adenine dinucleotide hydrogen (NADH)-dependent oxidoreductase. It is involved in catalyzing the reductive amination of aliphatic 2-oxo-acids to their respective L-amino acids.