90919-32-7

Basic information

• Product Name: α-methoxy-p-chloropropiophenone
• Synonyms: α-methoxy-p-chloropropiophenone
• CAS NO: 90919-32-7
• Molecular Weight: 198.649
• Mol File: 90919-32-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α-methoxy-p-chloropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α-methoxy-p-chloropropiophenone(90919-32-7)
• EPA Substance Registry System: α-methoxy-p-chloropropiophenone(90919-32-7)

Safety Data

• Hazardous Substances Data: 90919-32-7(Hazardous Substances Data)

Upstream product

• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 1026945-81-2 4-Nitro-benzenesulfonic acid 2-(4-chloro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 6285-05-8 4'-chloropropiophenone 
• 108-90-7 chlorobenzene 
• 83022-49-5 2-Hydroxy-1,1-dimethoxy-1-(4-chlor-phenyl)-propan 
• 33695-59-9 2-methoxy-propanenitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 126918-29-4 2-chloro-1-(4-chlorophenyl)propan-1-one 

Downstream Products

• 151716-73-3 (R)-(+)-1-(4-chlorophenyl)-2-hydroxypropan-1-one 
• 169295-49-2 α-acetoxy-p-chloropropiophenone 
• 49656-24-8 1-(4-chlorophenyl)-2-hydroxypropan-1-one 

Relevant articles and documents

Intermolecular C-O Bond Formation with Alkoxyl Radicals: Photoredox-Catalyzed α-Alkoxylation of Carbonyl Compounds

Due to the high reactivity of alkoxyl (RO·) radicals and their propensity to easily undergo β-scission or Hydrogen Atom Transfer (HAT) reactions, intermolecular alkoxylations involving RO· radicals are barely described. We report herein for the first time the efficient intermolecular trapping of alkoxyl radicals by silyl enol ethers. This photoredox-mediated protocol enables the introduction of both structurally simple and more complex alkoxy groups into a wide range of ketones and amides.

A facile synthesis of secondary α-alkoxy or α-acetoxy aromatic ketones

The treatment of HNIB with aromatic ketones and subsequent solvolysis using alcohol or acetic acid in one-pot system makes it possible to give corresponding secondary α-alkoxy or α-acetoxy ketones in high yields.

Enzymes in Organic Synthesis: Lipase Catalyzed Resolution of Secondary α-Ketoalcohols

Resolution of several α-ketoalcohols of synthetic value using lipase as a catalyst is described.