91-44-1Relevant articles and documents
Permethylated NHC-Capped α- and β-Cyclodextrins (ICyDMe) Regioselective and Enantioselective Gold-Catalysis in Pure Water
Zhu, Xiaolei,Xu, Guangcan,Chamoreau, Lise-Marie,Zhang, Yongmin,Mouriès-Mansuy, Virginie,Fensterbank, Louis,Bistri-Aslanoff, Olivia,Roland, Sylvain,Sollogoub, Matthieu
supporting information, p. 15901 - 15909 (2020/10/12)
A series of water-soluble encapsulated copper(I), silver(I) or gold(I) complexes based on NHC-capped permethylated cyclodextrins (ICyDMe) were developed and used as catalysts in pure water for hydration, lactonization, hydroarylation and cycloisomerization reactions. ICyDMe ligands gave cavity-based high regioselectivity in hydroarylations, and high enantioselectivities in gold-catalyzed cycloisomerizations reactions giving up to 98 % ee in water. These ICyDMe are therefore useful ligands for selective catalysis in pure water.
Preparation method of 4-methyl-7-diethylaminocoumarin and application of preparation method
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Paragraph 0022-0041, (2020/08/26)
The invention belongs to the technical field of coumarin dye synthesis, and particularly relates to a preparation method of 4-methyl-7-diethylaminocoumarin and application of the preparation method. According to the technical schemes, m-hydroxy-N, N-diethylaniline and ethyl acetoacetate are subjected to a reaction, the molar ratio of the m-hydroxy-N, N-diethylaniline to the ethyl acetoacetate is 1: (1.5-2.2), part of the ethyl acetoacetate serves as a solvent, ethyl alcohol and water generated in the reaction are evaporated out while the reaction is conducted, then heat preservation is conducted for a period of time in a high-temperature section, and therefore, the yield is increased; after the reaction is finished, glacial acetic acid and water are added, stirring is performed, and cooling is performed to 0 DEG C; spin-drying is performed, so that a crude product is obtained; and refining is performed with methanol, so that the finished product 4-methyl-7-diethylaminocoumarin is obtained. According to the 4-methyl-7-diethylaminocoumarin prepared by the method, the content of the 4-methyl-7-diethylaminocoumarin can reach 99.5%, the yield of the 4-methyl-7-diethylaminocoumarin is ashigh as 95%, the quality of the product is high; and the defects of low purity and low yield of a traditional preparation method can be overcome. The preparation method is simple. With the preparation method adopted, industrial production is easy to carry out.
Process for preparing particles which have a hydrophilic core coated with a hydrophobic polymeric layer
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, (2016/06/01)
This method of preparing particles having a hydrophilic core coated with a hydrophilic core coated with a hydrophobic polymeric layer includes the steps of: preparing an aqueous phase comprising at least one hydrophilic optical brightener or colorant; preparing an organic phase including at least one hydrophobic polymer; forming a water-in-oil inverse emulsion by adding the aqueous phase into the organic phase; forming the particles by thermal quenching of the emulsion; and isolating the particles thus obtained.