91131-86-1

Basic information

• Product Name: 5,7-dimethylindolin-2-one
• Synonyms: 5,7-dimethylindolin-2-one;2-Methyl-5,7-diMethyl-1H-indole;2,5,7-TriMethyl 1H-indole
• CAS NO: 91131-86-1
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 161
• Mol File: 91131-86-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,7-dimethylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dimethylindolin-2-one(91131-86-1)
• EPA Substance Registry System: 5,7-dimethylindolin-2-one(91131-86-1)

Safety Data

• Hazardous Substances Data: 91131-86-1(Hazardous Substances Data)

Usage

General Description

5,7-dimethylindolin-2-one is a chemical compound with the molecular formula C11H11NO. It belongs to the class of organic compounds known as indolin-2-ones, and it is a derivative of indole. 5,7-dimethylindolin-2-one is a yellow liquid at room temperature and has a faint, sweet odor. It is commonly used in the synthesis of various pharmaceuticals and organic compounds due to its versatile chemical properties. 5,7-dimethylindolin-2-one has been studied for its potential antimicrobial and anti-inflammatory properties, making it a valuable target for medicinal chemistry research. Additionally, it has been investigated as a potential building block for the development of novel organic materials and dyes.

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Relevant articles and documents

Preparation method of 7-alkylindole derivative

The invention discloses a preparation method of a 7alkyl indole derivative as shown in a formula (4), which comprises the following steps: by using Nprotective indole as shown in a formula (1) and halogenated hydrocarbon as shown in a formula (2) as raw materials, carrying out C-H alkylation reaction by a mechanical grinding method under the action of a manganese catalyst, magnesium metal and an additive, and carrying out deprotection reaction to obtain the 7alkyl indole derivative as shown in the formula; obtaining a 7alkyl indole derivative as shown in a formula (4); according to the method,carrying out cheap metal catalyzed indole C7-site alkylation reaction in a mechanical grinding mode for the first time, the 7alkyl indole derivative is rapidly and efficiently prepared, the adaptability of an indole substrate is greatly widened, and the method has the remarkable advantages of simple reaction system, convenience in operation, mild reaction conditions, specific reaction sites and the like.

Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: The synthesis of indoles by sequential aryl amination/heck coupling

A method has been devised for the microwave-assisted, continuous-flow preparation of indole alkaloids by a two-step aryl amination/cross-coupling sequence of bromoalkenes and 2-bromoanilines. This process requires both the presence of a metal-lined flow tube (a 1180 micron capillary) and the Pd PEPPSI-IPr catalyst; without either, the catalyst or the film, there is zero turnover of this catalytic process. A silver film has been shown to provide some conversion (48-62%), but optimal results (quantitative) across a variety of bromoalkenes and bromoanilines were achieved by using a highly porous palladium film. Possible roles for the Pd film are considered, as is the interplay of the catalyst and the film.