912-60-7

Basic information

• Product Name: NOSCAPINE HYDROCHLORIDE
• Synonyms: NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;(3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;capvalhydrochloride;coscopinhydrochloride
• CAS NO: 912-60-7
• Molecular Formula: C₂₂H₂₄NO₇*Cl
• Molecular Weight: 449.88
• EINECS: 213-014-9
• Product Categories: Inhibitors
• Mol File: 912-60-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 221-223 °C(lit.)
• Boiling Point: 565.3°Cat760mmHg
• Flash Point: 295.7°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 8.42E-13mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
• Merck: 13,6752
• CAS DataBase Reference: NOSCAPINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NOSCAPINE HYDROCHLORIDE(912-60-7)
• EPA Substance Registry System: NOSCAPINE HYDROCHLORIDE(912-60-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36
• RIDADR: 1544
• WGK Germany: 3
• RTECS: NP7225000
• F: 10
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 912-60-7(Hazardous Substances Data)

Usage

Description

NOSCAPINE HYDROCHLORIDE is an alkaloid compound derived from the opium poppy plant, Papaver somniferum. It exhibits a range of pharmacological properties, including being a bradykinin B and tubulin inhibitor, and has potential anti-viral activity.

Uses

Used in Pharmaceutical Industry:
NOSCAPINE HYDROCHLORIDE is used as a topical fluoroquinolone antibiotic for the treatment of acne. It helps to reduce inflammation and bacterial growth, promoting skin healing and reducing acne lesions.
Used in Cough Suppressants:
NOSCAPINE HYDROCHLORIDE is used as an anti-tussive agent in the pharmaceutical industry. It works by inhibiting the cough reflex, providing relief from persistent coughing.
Used in Antiviral Applications:
NOSCAPINE HYDROCHLORIDE is used as an anti-viral agent due to its ability to inhibit the replication of certain viruses. Its antiviral properties make it a potential candidate for the development of new antiviral therapies.
Used in Cancer Treatment:
NOSCAPINE HYDROCHLORIDE is used as a bradykinin B and tubulin inhibitor in cancer treatment. Its ability to inhibit these targets may help to slow down the growth and spread of cancer cells, making it a potential therapeutic agent for various types of cancer.

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

InChI:InChI=1/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/p+1/t17-,18+/m1/s1

Downstream Products

• 946068-67-3 (S)-6,7-dimethoxy-3-((R)-4-methoxy-9-(4-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one 
• 4593-97-9 N-Nor-1-methylcorypalline 
• 569-31-3 meconin 
• 550-10-7 hydrocotarnine 
• 19641-12-4 6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol