91397-11-4

Basic information

• Product Name: 5-Methyl-3-isoxazolecarboxylic Acid Benzylidenehydrazide
• Synonyms: 5-Methyl-3-isoxazolecarboxylic Acid Benzylidenehydrazide;5-Methyl-3-isoxazolecarboxylic Acid (PhenylMethylene)hydrazide;5-methyl-isoxazole-3-carboxylic acid benzylidenehydrazide
• CAS NO: 91397-11-4
• Molecular Formula: C₁₂H₁₁N₃O₂
• Molecular Weight: 229.23464
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 91397-11-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Solubility: Dichloromethane, DMSO, Methanol
• PKA: 11.40±0.46(Predicted)
• CAS DataBase Reference: 5-Methyl-3-isoxazolecarboxylic Acid Benzylidenehydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-3-isoxazolecarboxylic Acid Benzylidenehydrazide(91397-11-4)
• EPA Substance Registry System: 5-Methyl-3-isoxazolecarboxylic Acid Benzylidenehydrazide(91397-11-4)

Safety Data

• Hazardous Substances Data: 91397-11-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Isocarboxazid intermediate.

Upstream product

• 62438-03-3 5-methylisoxazole-3-carboxylic acid hydrazide 
• 100-52-7 benzaldehyde 

Downstream Products

• 101670-68-2 N-benzyl-N,N'-bis-(5-methyl-isoxazole-3-carbonyl)-hydrazine 
• 59-63-2 isocarboxazid 

Relevant articles and documents

Reductive alkylation of hydrazine derivatives with α-picoline-borane and its applications to the syntheses of useful compounds related to active pharmaceutical ingredients

An efficient method for the direct reductive alkylation of hydrazine derivatives with α-picoline-borane has been developed to synthesize a variety of N-alkylhydrazine derivatives. This method provided N,N-dialkylhydrazine derivatives and N-monoalkylhydrazine derivatives upon fine-tuning of the substrates and the reagent equivalency in a one-pot manner. The method was applied to the synthesis of active pharmaceutical ingredients of therapeutic drugs such as isocarboxazid.

Monoamine oxidase inhibitors. I. 1-Alkyl and 1-aralkyl-2-(picolinoyl and 5-methyl-3-isoxazolyl-carbonyl)hydrazines.

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