914927-40-5

Basic information

• Product Name: 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-
• Synonyms: 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-;3-(4-Hydroxybutyl)-1H-indole-5-carbonitrile;1H-Indole-5-carbonitrile, 3-(4-hydroxybuty
• CAS NO: 914927-40-5
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.26306
• Mol File: 914927-40-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 467℃
• Flash Point: 236℃
• Appearance: /
• Density: 1.21
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-(914927-40-5)
• EPA Substance Registry System: 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-(914927-40-5)

Safety Data

• Hazardous Substances Data: 914927-40-5(Hazardous Substances Data)

Usage

Description

1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)is an organic compound that serves as an impurity in Vilazodone (V265000), a pharmaceutical drug. Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist, which is under clinical evaluation for the treatment of major depression.

Uses

Used in Pharmaceutical Industry:
1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)is used as an impurity in the development and production of Vilazodone (V265000), a drug being evaluated for its efficacy in treating major depression. Its presence is significant for quality control and safety assessments during the clinical evaluation process.

Upstream product

• 15861-24-2 1H-indole-5-carbonitrile 
• 276863-95-7 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 873-74-5 4-Aminobenzonitrile 
• 34067-76-0 6-hydroxyhexanal 
• 2863-98-1 4-hydrazinobenzonitrile hydrochloride 

Downstream Products

• 163521-12-8 vilazodone 

Relevant articles and documents

Practical and Scalable Manufacturing Process for a Novel Dual-Acting Serotonergic Antidepressant Vilazodone

Vilazodone combines the effects of a selective serotonin reuptake inhibitor with the 5-HT1A receptor partial agonist activity. Here, we report the development of a viable and scalable process for manufacturing vilazodone that features a convergent synthetic approach, with low cost and high purity. The key indole synthesis was improved to first make up the hydrazone intermediate and then modify a pendant hydroxy group to realize a much increased overall yield. This process was successfully used to prepare >2 kg of vilazodone hydrochloride with a total yield of 56.2% and purity of 99.93%.

Substituted indole compound and method and use thereof

The invention provides a new indole compound, pharmaceutically acceptable salts and medicinal preparations thereof, and a use of the new indole compound in selective inhibition of 5-hydroxytryptamine reuptake and /or excitation of a 5-HT1A receptor. The invention also relates to medicinal compositions comprising the compounds, and a method for treating the central nervous system dysfunction of mammals, especially humans by using the medicinal compositions.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are novel heteroaryl compounds, pharmaceutically acceptable salts and pharmaceutical formulations thereof for selectively inhibiting serotonin reuptake and/or acting as 5-HT1A receptor agonists. Also provided herein are pharmaceutical compositions comprising the heteroaryl compounds and methods of using the pharmaceutical compositions in treating central nervous system (CNS) dysfunction in a mammal, especially a human being.