915038-24-3 Usage
Description
Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)is a chemical compound derived from the bile acid family, specifically as an impurity of obeticholic acid. It possesses a unique molecular structure with a 6-ethylidene group, 3-hydroxy, and 7-oxo functional groups, which may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)is used as an impurity in the synthesis of obeticholic acid for its potential therapeutic applications. Obeticholic acid is a farnesoid X receptor (FXR) agonist, which has been approved for the treatment of primary biliary cirrhosis and is being investigated for other liver-related diseases.
Used in Research and Development:
Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)can be utilized in research and development for understanding the structure-activity relationship of bile acid derivatives and their potential applications in drug discovery. Its unique structural features may provide insights into the development of novel therapeutic agents targeting various diseases.
Used in Quality Control and Analysis:
As an impurity of obeticholic acid, Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)is used in quality control and analysis to ensure the purity and safety of the final drug product. Analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and nuclear magnetic resonance (NMR) can be employed to detect and quantify its presence in pharmaceutical formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 915038-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,0,3 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 915038-24:
(8*9)+(7*1)+(6*5)+(5*0)+(4*3)+(3*8)+(2*2)+(1*4)=153
153 % 10 = 3
So 915038-24-3 is a valid CAS Registry Number.
915038-24-3Relevant articles and documents
Preparation method of obeticholic acid
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Paragraph 0095-0097, (2020/07/07)
The invention relates to a preparation method of obeticholic acid, in particular to a compound shown as a formula III which is described in the specification, a preparation method of the compound anda method for preparing obeticholic acid through the compound III. The method has the advantages of mild reaction conditions, few byproducts, simplicity and convenience in operation, high total yield and the like, and is suitable for large-scale production.
PROCESS FOR THE PREPARATION OF 3α,7α-DIHYDROXY6α-ETHYL-5β-CHOLAN-24-OIC ACID
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, (2019/08/12)
The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid which are useful in the preparation of pure 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid.
Preparation method of obeticholic acid and intermediate thereof
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, (2018/07/30)
The invention discloses a preparation method of obeticholic acid and an intermediate thereof. The invention provides a preparation method of a compound V. The preparation method of the compound V comprises the following steps: carrying out hydroxyl protective reaction on a compound VI and a hydroxyl protective reagent to obtain the compound V. The preparation method is simple and convenient to operate, low in cost, gentle in condition, environmentally friendly and suitable for industrialization.