915306-64-8

Basic information

• Product Name: 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene
• Synonyms: 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene
• CAS NO: 915306-64-8
• Molecular Weight: 319.447
• Mol File: 915306-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene(915306-64-8)
• EPA Substance Registry System: 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene(915306-64-8)

Safety Data

• Hazardous Substances Data: 915306-64-8(Hazardous Substances Data)

Upstream product

• 161661-47-8 (-)-(1R,2S,5R)-8-phenylmenthyl (1S,3S,4R)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate 
• 542-92-7 cyclopenta-1,3-diene 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 915306-61-5 (-)-(1S,3S,4R)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-en-3-ylmethanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 915306-69-3 3-benzyloxymethyl-2-(1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]heptane-5,6-diol 

Relevant articles and documents

Stereoselective synthesis of polyhydroxylated pyrrolidines: a route to novel 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes

An efficient preparation of racemic and chiral 2-functionalized-3,5-bis(hydroxymethyl)pyrrolidines is described. The method uses 2-azabicyclo[2.2.1]hept-5-enes, readily obtained from glyoxylates of aliphatic amines and cyclopentadiene, as starting material. The hydroxylation of the double bond followed by the oxidative cleavage of the six-membered ring and in situ reduction of the dialdehyde intermediate gives the title pyrrolidines.