916489-11-7

Basic information

• Product Name: (R)-5,6-dihydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one
• Synonyms: (R)-5,6-dihydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one
• CAS NO: 916489-11-7
• Molecular Weight: 259.28
• Mol File: 916489-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5,6-dihydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5,6-dihydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one(916489-11-7)
• EPA Substance Registry System: (R)-5,6-dihydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one(916489-11-7)

Safety Data

• Hazardous Substances Data: 916489-11-7(Hazardous Substances Data)

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 916489-09-3 (R)-5-hydroxy-7-cyanohept-2-ynoic acid ethyl ester 
• 1643-73-8 (4-fluorobenzyl)magnesium chloride 

Downstream Products

• 916489-22-0 (2S,4R)-1-propyl-2-(3-aminopropyl)-4-(4-fluorobenzyl)piperidine 
• 916489-21-9 (2S,4R)-1-propyl-2-(2-cyanoethyl)-4-(4-fluorobenzyl)piperidine 
• 916489-16-2 (4S,6R)-tetrahydro-6-(2-cyanoethyl)-4-(4-fluorobenzyl)-2H-pyran-2-one 

Relevant articles and documents

Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: Application to the CCR3 antagonist IS811

A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from commercial (R)-epichlorohydrin, while the C4 stereocent