91741-74-1

Basic information

• Product Name: 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester
• CAS NO: 91741-74-1
• Molecular Weight: 926.986
• Mol File: 91741-74-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester(91741-74-1)
• EPA Substance Registry System: 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester(91741-74-1)

Safety Data

• Hazardous Substances Data: 91741-74-1(Hazardous Substances Data)

Upstream product

• 14533-84-7 pentafluorophenyl trifloroacetate 
• 91711-92-1 N-t-Butoxycarbonyl-(R)-prolyl-(R)-leucyl-(R)-valyl-2-<1-(R)-amino-3-cyano-prop-1-yl>-thiazole-4-carbonyl-2-thiazole-4-carboxylic acid ethyl ester 
• 328-38-1 (R)-leucine 
• 91741-73-0 2-[(R)-1-((R)-2-{(R)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carboxylic acid 
• 91711-91-0 N-t-Butoxycarbonyl-(R)-prolyl-(R)-leucyl-(R)-valyl-2<1-(R)-amino-3-cyano-prop-1-yl>thiazole-4-carboxylic acid ethyl ester 
• 91711-90-9 (R)-2-(1-Amino-3-cyanpropyl)-4-thiazolcarbonsaeure-ethylester 
• 33911-16-9 N-t-Butoxycarbonyl-(R)-valine pyridyl-2-thiolester 
• 91711-95-4 N-(tert-butoxycarbonyl)-(R)-prolyl-(R)-leucine 
• 102185-34-2 N-t-butoxycarbonyl-(R)-proline N-hydroxysuccuinimide ester 
• 91741-72-9 N-t-Butyloxycarbonyl-(R)-valyl-2-<1-(R)-amino-3-cyanoprop-1-yl>thiazole-4-carboxylic acid ethyl ester 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 54848-33-8 (S)-tetrahydro-5-oxo-2-furancarbonyl chloride 
• 91711-86-3 2-((S)-5-Oxo-tetrahydro-furan-2-yl)-thiazole-4-carboxylic acid ethyl ester 
• 91711-84-1 (S)-(-)-2-Oxo-4,5-dihydro-3H-furan-2-carbonsaeureamid 

Relevant articles and documents

Amino Acids and Peptides; 60. Synthesis of Biologically Active Cyclopeptides; 10. Synthesis of 16 Structural Isomers of Dolastatin 3; II: Synthesis of the Linear Educts and the Cyclopeptides

Sixteen isomers of the cancerostatic cyclopeptide Dolastatin 3 of marine origin are synthesized.The proposed structure of Dolastatin 3 is proved to be not correct.