918488-41-2

Basic information

• Product Name: 6-Isoquinolinol, 5-chloro-
• Synonyms: 6-Isoquinolinol, 5-chloro-;5-chloro-6-Isoquinolinol;5-chloro-6-hydroxyisoquinoline
• CAS NO: 918488-41-2
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.6
• Mol File: 918488-41-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Isoquinolinol, 5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Isoquinolinol, 5-chloro-(918488-41-2)
• EPA Substance Registry System: 6-Isoquinolinol, 5-chloro-(918488-41-2)

Safety Data

• Hazardous Substances Data: 918488-41-2(Hazardous Substances Data)

Usage

General Description

6-Isoquinolinol, 5-chloro- is a chemical compound that belongs to the isoquinolines family. It is a derivative of isoquinolinol with a chlorine atom substituent at the 5-position. 6-Isoquinolinol, 5-chloro- has shown potential pharmacological properties and has been studied for its potential use in pharmaceutical applications. It may be used as a building block in the synthesis of various organic compounds and pharmaceuticals due to its unique structure and reactivity. Additionally, research has suggested that 6-Isoquinolinol, 5-chloro- may have antimicrobial and antifungal properties, making it a potential candidate for drug development in these therapeutic areas. Overall, this chemical shows promise for various applications in the pharmaceutical and industrial sectors.

Upstream product

• 7651-82-3 isoquinolin-6-ol 

Relevant articles and documents

RadH: A Versatile Halogenase for Integration into Synthetic Pathways

Flavin-dependent halogenases are useful enzymes for providing halogenated molecules with improved biological activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromatic scaffolds. Site-directed mutagenesis of RadH was used to identify catalytic residues and provide insight into the mechanism of fungal halogenases. A high-throughput fluorescence screen was also developed, which enabled a RadH mutant to be evolved with improved properties. Finally we demonstrate how biosynthetic genes from fungi, bacteria, and plants can be combined to encode a new pathway to generate a novel chlorinated coumarin “non-natural” product in E. coli.

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES

The invention relates to 6-substituted isoquinoline derivatives of the Formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.