7651-82-3 Usage
Description
Isoquinolin-6-ol, also known as 6-Hydroxyisoquinoline, is a white to light yellow crystal powder with significant applications in various scientific and industrial fields. It is an organic compound belonging to the isoquinoline family, which is characterized by its unique chemical structure and properties.
Uses
Used in Proteomics Research:
Isoquinolin-6-ol is used as a reagent in proteomics research, specifically in the preparation of isoquinoline derivatives. These derivatives act as protease inhibitors against trypsin, an enzyme that plays a crucial role in protein digestion and proteolysis. By inhibiting trypsin, these isoquinoline derivatives can help researchers study and understand the mechanisms of protein degradation and the role of proteases in various biological processes.
Used in Pharmaceutical Industry:
Isoquinolin-6-ol is used as a reagent in the development of a novel series of compounds that act as Wnt signaling pathway inhibitors. The Wnt signaling pathway is involved in various cellular processes, including cell proliferation, differentiation, and migration. Dysregulation of this pathway has been implicated in several diseases, including cancer. By acting as Wnt signaling pathway inhibitors, the compounds derived from Isoquinolin-6-ol can potentially be used in the development of therapeutic agents for the treatment of diseases associated with Wnt pathway dysregulation.
Used in Chemical Synthesis:
Isoquinolin-6-ol serves as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique chemical structure allows for further functionalization and modification, making it a valuable building block in the development of new molecules with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 7651-82-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,5 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7651-82:
(6*7)+(5*6)+(4*5)+(3*1)+(2*8)+(1*2)=113
113 % 10 = 3
So 7651-82-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NO/c11-9-2-1-8-6-10-4-3-7(8)5-9/h1-6,11H
7651-82-3Relevant articles and documents
Time-dependent enantiodivergent synthesis via sequential kinetic resolution
Tu, Hang-Fei,Yang, Pusu,Lin, Zi-Hua,Zheng, Chao,You, Shu-Li
, p. 838 - 844 (2020/07/03)
The preparation of both enantiomers of chiral molecules is among the most fundamental tasks in organic synthesis, medicinal chemistry and materials science. Achieving this goal typically requires reversing the absolute configuration of the chiral component employed in the reaction system that is being used. The task becomes challenging when the natural source of the chiral component is not available in both configurations. Herein, we report a time-dependent enantiodivergent synthesis, in which an Ir-catalysed allylic substitution reaction uses one catalyst sequentially to promote two kinetic resolution reactions, enabling the synthesis of both enantiomers of the product using the same enantiomer of a chiral catalyst. The appropriate permutation of individual reaction rates is essential for the isolation of the chiral products in opposite configurations with high enantiopurity when quenched at different reaction times. This work provides an alternative solution for the preparation of both enantiomers of chiral molecules. [Figure not available: see fulltext.].
Wnt signal pathway inhibitor and use thereof
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Paragraph 0047; 0169-0172, (2017/08/10)
The invention relates to heterocyclic compounds with Wnt signal channel inhibition activity, particularly including compounds, pharmaceutically acceptable salts, various isotopes, various isomers or various crystal structures thereof having a structure represented by a general formula I (shown in the specification). By the compounds and a composition of the compounds, a Wnt signal channel can be effectively inhibited and diseases related to the Wnt signal channel can be treated or prevented.
ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE
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Page/Page column 35, (2008/06/13)
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I); useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.