918523-45-2

Basic information

• Product Name: Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)-benzoate
• Synonyms: Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)-benzoate
• CAS NO: 918523-45-2
• Molecular Formula: C₁₇H₁₇F₂NO₄S
• Molecular Weight: 369.3829864
• Mol File: 918523-45-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)-benzoate(918523-45-2)
• EPA Substance Registry System: Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)-benzoate(918523-45-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 918523-45-2(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 501-53-1 benzyl chloroformate 
• 918523-44-1 3-amino-2,6-difluoro-benzoic acid benzyl ester 
• 10147-36-1 n-propanesulfonyl chloride 

Downstream Products

• 918504-27-5 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide 
• 1186194-32-0 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride 
• 1254565-63-3 propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide 
• 1244037-18-0 propane-1-sulfonic acid {3-[(5-cyano-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-amide 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 

Relevant articles and documents

PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.

PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.