92086-91-4Relevant articles and documents
One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole
Athanasellis, Giorgos,Gavrielatos, Efstathios,Igglessi-Markopoulou, Olga
, p. 2691 - 2692 (2002)
A novel one-pot synthetic route to 4-acetylamino-2-cyano-3-hydroxybut-2-enoates in good yields (63-71%) is reported. An HPLC analysis of these compounds showed very good enantiomeric excesses (90-94%), justifying the success of our methodology to maintain the stereochemical integrity of the starting materials used.