921599-50-0

Basic information

• Product Name: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one
• Synonyms: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one
• CAS NO: 921599-50-0
• Molecular Weight: 506.664
• Mol File: 921599-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one(921599-50-0)
• EPA Substance Registry System: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one(921599-50-0)

Safety Data

• Hazardous Substances Data: 921599-50-0(Hazardous Substances Data)

Upstream product

• 190906-91-3 3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester 
• 620-08-6 4-methoxypyridine 
• 873-62-1 m-cyanophenol 
• 363185-45-9 3-isopropoxybenzonitrile 
• 400771-44-0 3-propan-2-yloxyphenylmethanamine 
• 921599-67-9 1-(3-isopropoxybenzyl)-2-methylpiperidin-4-one 
• 75792-33-5 3-isopropoxybenzaldehyde 
• 26066-15-9 3-isopropoxybenzyl alcohol 
• 921599-78-2 benzyl (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-2-oxo-1,3,8-triazaspiro[4.5]dec-3-ene-8-carboxylate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 921599-74-8 benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate 
• 849928-34-3 benzyl 2-methyl-4-oxopiperidine-1-carboxylate 
• 921599-79-3 (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one 
• 26066-16-0 3-isopropoxybenzylchloride 

Relevant articles and documents

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

The IC50 of a beta-secretase (BACE-1) lead compound was improved ～200-fold from 11 μM to 55 nM through the addition of a single methyl group. Computational chemistry, small molecule NMR, and protein crystallography capabilities were used to com