924648-17-9

Basic information

• Product Name: 1-Propanone, 1-(5-fluoro-2-nitrophenyl)-
• Synonyms: 5-fluoro-2-nitropropiophenone;1-Propanone,1-(5-fluoro-2-nitrophenyl)
• CAS NO: 924648-17-9
• Molecular Formula: C9H8FNO3
• Molecular Weight: 197.166
• Mol File: 924648-17-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(5-fluoro-2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(5-fluoro-2-nitrophenyl)-(924648-17-9)
• EPA Substance Registry System: 1-Propanone, 1-(5-fluoro-2-nitrophenyl)-(924648-17-9)

Safety Data

• Hazardous Substances Data: 924648-17-9(Hazardous Substances Data)

Usage

Physical appearance

Yellow crystalline solid.

Usage

Commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Solubility

Insoluble in water, soluble in organic solvents such as ethanol and acetone.

Applications

Building block in the production of various fine chemicals, used in research and development laboratories for its useful chemical properties.

Safety concerns

Potential irritant to skin, eyes, and respiratory system, should be handled with caution in a laboratory setting.

Upstream product

• 455-67-4 1-(3-fluorophenyl)propan-1-one 
• 456-48-4 3-Fluorobenzaldehyde 
• 458-02-6 3-fluorobenzaldehyde oxime 
• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 453518-19-9 1-(5-hydroxy-2-nitrophenyl)propan-1-one 
• 35364-15-9 2'-amino-5'-hydroxypropiophenone 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 97682-44-5 irinotecan 
• 100286-90-6 irinotecan hydrochloirde 

Relevant articles and documents

Scalable synthetic route to 2-amino-5-hydroxypropiophenone: Efficient formal synthesis of irinotecan

2-Amino-5-hydroxypropiophenone, a key precursor in the total synthesis of irinotecan, has been synthesized. Regioselective nitration and a SNAr displacement are the key steps involved in this strategy, which is high yielding, is economical, and has been performed on a plant scale. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES

The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.