925234-67-9Relevant articles and documents
2 -methoxyamino -4 -substituted cyclohexylsulfonamide compound and preparation method and application thereof
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Paragraph 0029-0034, (2021/10/30)
The invention belongs to the field of agricultural chemicals, and particularly relates to N - (2 -trifluoromethyl -4 - chlorophenyl) -2 -methoxyamino -4 -substituted cyclohexylsulfonamide compound as well as a preparation method and application thereof as
Novel sulfonamides against Botrytis cinerea with no positive cross-resistance to commercial fungicides: Design, synthesis and SAR study
Cai, Nan,He, Lu,Wang, Kai,Feng, Zhihui,Cui, Zining,Ji, Mingshan,Qi, Zhiqiu,Qin, Peiwen,Li, Xinghai
, (2020/01/03)
Thirty-four novel compounds were synthesized using chesulfamide (N-(2-trifluoromethyl-4-chlorophenyl)-2-oxocyclohexyl sulfonamide), a high-profile fungicide, as the lead compound, and their structures were characterized by 1H NMR, 13C NMR, MS and elemental analysis. Additionally, the structure of (1S,2R)-2-((3-bromophenethyl)amino)-N-(4-chloro-2-trifluoromethylphenyl)cyclohexane-1-sulfonamide (IV-9) was confirmed by X-ray single crystal diffraction. The mycelium inhibition tests, spore germination inhibition tests, tomato pot tests and field trials were performed against strains of B. cinerea. Bioassay results showed that most of target compounds had good fungicidal activity against B. cinerea, in particular, IV-9 exhibited similar or superior effects to procymidone, boscalid and pyrisoxazole in all in vitro and in vivo tests. Moreover, there was no positive cross-resistance found between the compound IV-9 and eight commercial fungicides (azoxystrobin, boscalid, chlorothalonil, diethofencarb, fludioxonil, procymidone, pyrimethanil and pyrisoxazole) in the cross-resistance validation test performed by an innovative method.
Design, synthesis and fungicidal activity of novel 2-substituted aminocycloalkylsulfonamides
Liu, Caixiu,Yan, Xiaojing,Wang, Minlong,Qin, Peiwen,Qi, Zhiqiu,Ji, Mingshan,Liu, Xingyu,Babu, P. Vijaya,Li, Xinghai,Cui, Zi-Ning
, p. 271 - 276 (2016/12/27)
A series of novel 2-substituted aminocycloalkylsulfonamides were designed and synthesized by highly selective N-alkylation reaction, whose structures were characterized by1H NMR,13C NMR and HRMS. Among them, the configuration of compounds III12 and III20 were confirmed by X-ray single crystal diffraction. Bioassays demonstrated that the title compounds had considerable effects on different strains of Botrytis cinerea and Pyricularia grisea. Comparing with positive control procymidone (EC50?=?10.31?mg/L), compounds III28, III29, III30 and III31 showed excellent fungicidal activity against a strain of B. cinerea (CY-09), with EC50values of 3.17, 3.04, 2.54 and 1.99?mg/L respectively. Their in vivo fungicidal activities were also better than the positive controls cyprodinil, procymidone, boscalid and carbendazim in pot experiments. Moreover, the fungicidal activity of III28 (EC50?=?4.62?mg/L) against P. grisea was also better than that of the positive control isoprothiolane (EC50?=?6.11?mg/L). Compound III28 would be great promise as a hit compound for further study based on the structure-activity relationship.