92646-33-8

Basic information

• Product Name: 2-amino-3,3-diphenyl-1-propanol
• Synonyms: 2-amino-3,3-diphenyl-1-propanol
• CAS NO: 92646-33-8
• Molecular Weight: 227.306
• Mol File: 92646-33-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-3,3-diphenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3,3-diphenyl-1-propanol(92646-33-8)
• EPA Substance Registry System: 2-amino-3,3-diphenyl-1-propanol(92646-33-8)

Safety Data

• Hazardous Substances Data: 92646-33-8(Hazardous Substances Data)

Upstream product

• 270078-91-6 5-(diphenylmethyl)imidazolidine-2,4-dione 
• 947-91-1 Diphenylacetaldehyde 
• 93406-82-7 ethyl 2-amino-3,3-diphenylpropanoate 
• 62653-26-3 2-amino-3,3-diphenylpropionic acid 

Downstream Products

• 144899-55-8 rac-3-acryloyl-5,5-dimethyl-4-(diphenylmethyl)oxazolidine 
• 144899-56-9 rac-3-acryloyl-5,5-pentamethylene-4-(diphenylmethyl)oxazolidine 
• 156101-79-0 5-[((N-(1-((3,5-Bis(trifluoromethyl)phenyl) methyloxy)-3,3-diphenylprop-2-yl)-N-methyl)amino)methyl]-2,3-dihydro-4H-1,2,4-triazol-3-one 
• 156101-98-3 2-N-t-butoxycarbonyl-N-methylamino-1-((3,5-bis (trifluoromethyl)phenyl)methyloxy)-3,3-diphenylpropane 
• 147148-57-0 1-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-(N-t-butoxy carbonylamino)-3,3-diphenylpropane 
• 147148-58-1 2-amino-1-((3',5'-bis(trifluoromethyl)phenyl)methyloxy)-3,3-diphenylpropane 
• 107202-40-4 (R,S)-2-(t-boc-amino)-3,3-dicyclohexylpropan-1-ol 
• 144899-46-7 rac-2,2-dimethyl-4-(diphenylmethyl)oxazolidine 
• 144899-47-8 rac-2,2-pentamethylene-4-(diphenylmethyl)oxazolidine 
• 107202-37-9 (1-hydroxymethyl-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Bisoxazoline and bioxazoline chiral ligands bearing 4-diphenylmethyl shielding substituents. Diels-Alder reaction of cyclopentadiene with 3-acryloyl-2-oxazolidinone catalyzed by the aqua nickel(II) complex

Enantiopure 2-amino-3,3-diphenyl-1-propanol was synthesized by the hidantoin route starting from diphenyl-acetaldehyde followed by subsequent functional group transformations and optical resolution by a chiral HPLC. The amino alcohol can be converted into two new chiral ligands: 4,4'-bis(diphenylmethyl)-2,2'-bioxazoline and 2,2'-isopropylidenebis(4-diphenylmethyloxazoline), and further to complexes with copper(II) trifluoromethanesulfonate and nickel(II) perchlorate hexahydrate. The nickel(II) aqua complex obtained from the bisoxazoline effectively catalyzed the Diels-Alder reactions of cyclopentadiene with 3-acryloyl-2-oxazolidinone in high endo-selectivities and moderate enantioselectivities via a square planar transition structure.

2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists

Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR 8 (R 8 is H or C 1-6 alkyl); R 1 is H, optionally substituted C 1-6 alkyl, p