927-62-8Relevant articles and documents
Palladium-Assisted Amination of Olefins. A Mechanistic Study
Hegedus, Louis S.,Akermark, Bjorn,Zetterberg, Krister,Olsson, Lars F.
, p. 7122 - 7126 (1984)
The mechanism of the palladium-assisted amination of olefins has been studied by low-temperature NMR and ultraviolat spectroscopy, conductivity measurements, and stoichiometry and exchange studies.The specific sequence of steps followed strongly depends on the temperature of amine.With dimethylamine, the sequence consists of cleavage of the chloride bridge by the amine to give a single olefin-palladium-amine complex (2).This undergoes amination of the olefin and concomitant cyclization to form the β-aminoalkylpalladium complex (3) directly and dimethylammonium hydrochloride.In contrast, with diethylamine, the initially formed olefin-palladium-amine complex undergoes amination to form a discrete zwitterionic complex (6).This reacts slowly with additional added amine to give the chelating β-aminoalkylpalladium complex (7).
Intermittent synthesis method N and N -dimethyl n-butylamine
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Paragraph 0031-0034, (2021/09/26)
The invention relates to N. The invention N-dimethyln-butylamine intermittent synthesis method. Some conversion rates of the main synthetic method of the prior art are relatively low, and some byproducts can be generated, the separation difficulty is increased, the method is economical, N - methylbutylamine is not generated, the separation difficulty is increased, and the production difficulty is large. The method is characterized in that n-butylamine and N-formaldehyde are used as raw materials, and the molar ratio of n-butylamine, n-butylamine and formaldehyde is prepared under the conditions N - and 37 - 40% through nickel catalytic hydrogenation. 60 - 90 °C. 2 - 4 mpa 2 - 1 . 2.6 1. To the invention, a new nickel catalyst is selected. The catalyst cost is reduced, the reaction is prepared by taking n-butylamine and formaldehyde as raw materials, the reaction is simple, the selectivity is good, and the yield is higher.
Efficient Cobalt-Catalyzed Methylation of Amines Using Methanol
Liu, Zhenghui,Yang, Zhenzhen,Yu, Xiaoxiao,Zhang, Hongye,Yu, Bo,Zhao, Yanfei,Liu, Zhimin
supporting information, p. 4278 - 4283 (2017/10/23)
The methylation of amines using methanol is a promising route to synthesize N-methylamines, and the development of cheap and efficient catalytic system for this reaction is of great significance. Herein, we reported a cobalt (Co)-based catalytic system, which was in situ formed from commercially available Co precursor and a tetradentate phosphine ligand P(CH2CH2PPh2)3 combined with K3PO4. This catalystic system was very effective for the selective production of dimethylated products from aliphatic amines and monomethylated ones from aromatic amines. The reaction mechanism was further investigated by control and isotope labelling experiments. (Figure presented.).
