928032-23-9 Usage
Description
6-Nitroisoquinolin-1(2H)-one is an organic compound that features a nitro group attached to the isoquinoline core. It is a versatile intermediate in the synthesis of various pharmaceuticals and organic compounds due to its unique structure and reactivity.
Uses
Used in Pharmaceutical Industry:
6-Nitroisoquinolin-1(2H)-one is used as a reactant for the preparation of macrocyclic compounds, specifically as factor VIIa inhibitors. These macrocyclic compounds have potential applications in the development of anticoagulant drugs, which are essential for the prevention and treatment of blood clot-related disorders.
In the synthesis process, 6-Nitroisoquinolin-1(2H)-one serves as a key building block, allowing chemists to create complex macrocyclic structures with specific biological activities. The factor VIIa inhibitors derived from this compound can modulate the coagulation cascade, providing a targeted approach to managing thrombotic events and associated health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 928032-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,8,0,3 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 928032-23:
(8*9)+(7*2)+(6*8)+(5*0)+(4*3)+(3*2)+(2*2)+(1*3)=159
159 % 10 = 9
So 928032-23-9 is a valid CAS Registry Number.
928032-23-9Relevant articles and documents
Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides
Bhuyan, Samuzal,Chhetri, Karan,Hossain, Jagir,Jana, Saibal,Mandal, Susanta,Roy, Biswajit Gopal
, p. 5049 - 5055 (2021/07/29)
Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.
MACROCYCLIC FACTOR VIIA INHIBITORS
-
, (2014/01/08)
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
