92850-22-1

Basic information

• Product Name: 1-(4-methylphenyl)-2-(phenylamino)ethanone
• Synonyms: 1-(4-methylphenyl)-2-(phenylamino)ethanone
• CAS NO: 92850-22-1
• Molecular Weight: 225.29
• Mol File: 92850-22-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-2-(phenylamino)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-2-(phenylamino)ethanone(92850-22-1)
• EPA Substance Registry System: 1-(4-methylphenyl)-2-(phenylamino)ethanone(92850-22-1)

Safety Data

• Hazardous Substances Data: 92850-22-1(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 108-88-3 toluene 
• 62-53-3 aniline 
• 619-41-0 4-(bromoacetyl)toluene 
• 4209-24-9 p-methylphenacyl chloride 

Downstream Products

• 55577-25-8 2-(4-methylphenyl)-1H-indole 
• 1285494-77-0 3‐(phenylthio)‐2‐(p‐tolyl)‐1H‐indole 
• 1127405-03-1 1-(morpholin-4-yl)-2-(p-tolyl)ethane-1,2-dione 
• 1609985-38-7 (Z)-(5-(4-methylbenylidene)-1,2-diphenyl-2,5-dihydro-1H-pyrazole-3,4-diyl)bis(p-tolylmethanone) 
• 1401073-55-9 2-(1H-indol-3-yl)-2-(phenylamino)-1-(p-tolyl)ethanone 
• 1403656-41-6 (E)-2-(3-chlorophenyl)-N-(2-oxo-2-p-tolylethyl)-N-phenyl-N'-tosylacetamidine 
• 1403656-36-9 (E)-N-(2-oxo-2-p-tolylethyl)-N,2-diphenyl-N'-tosylacetamidine 
• 1403656-46-1 1,3-diphenyl-4-(4-methylphenyl)-2-tosylaminopyrrole 

Relevant articles and documents

Microwave-assisted, solvent-free Bischler indole synthesis

The solid-state reaction between anilines and phenacyl bromides in the presence of an equimolecular amount of sodium bicarbonate gives N-phenacylanilines. Microwave irradiation of mixtures of these compounds with anilinium bromides at 540 W for 45-60 s provides a mild, general, and environmentally friendly method for the synthesis of 2-arylindoles in 50-56% overall yields. A one-pot variation of the method, involving irradiation of 2:1 mixtures of anilines and phenacyl bromides, was also developed, allowing a simplified experimental procedure and leading to improved yields (52-75%). Georg Thieme Verlag Stuttgart.

Natural products as sources of new fungicides (V): Design and synthesis of acetophenone derivatives against phytopathogenic fungi in vitro and in vivo

A series of acetophenone derivatives (10a–10i, 11, 12a–12g, 13a–13g, 14a–14d and 15a–15l) were designed, synthesized and evaluated for antifungal activities in vitro and in vivo. The antifungal activities of 53 compounds were tested against several plant pathogens, and their structure–activity relationship was summarized. Compounds 10a–10f displayed better antifungal effects than two reference fungicides. Interestingly, the most potent compound 10d exhibited antifungal properties against Cytospora sp., Botrytis cinerea, Magnaporthe grisea, with IC50 values of 6.0–22.6 μg/mL, especially Cytospora sp. (IC50 = 6.0 μg/mL). In the in vivo antifungal assays, 10d displayed the significant protective efficacy of 55.3% to Botrytis cinerea and 73.1% to Cytospora sp. The findings indicated that 10d may act as a potential pesticide lead compound that merits further investigation.

Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

A general and mild method for the construction of a carbon-nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Amines, either aliphatic primary amines, aromatic primary amines or secondary amines can be used as the starting materials. When R2 was different from R3, two isomers would be observed. Therefore, this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.