92950-45-3

Basic information

• Product Name: 10-dehydro 10-deacetyl 7-epibaccatin V
• Synonyms: 10-dehydro 10-deacetyl 7-epibaccatin V
• CAS NO: 92950-45-3
• Molecular Weight: 542.583
• Mol File: 92950-45-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 10-dehydro 10-deacetyl 7-epibaccatin V(CAS DataBase Reference)
• NIST Chemistry Reference: 10-dehydro 10-deacetyl 7-epibaccatin V(92950-45-3)
• EPA Substance Registry System: 10-dehydro 10-deacetyl 7-epibaccatin V(92950-45-3)

Safety Data

• Hazardous Substances Data: 92950-45-3(Hazardous Substances Data)

Usage

Source

Derived from the Pacific yew tree (Taxus brevifolia)

Use

Commonly used in the synthesis of the anti-cancer drug paclitaxel (Taxol)

Chemical structure

Unique structure with multiple functional groups

Functional groups

Contains dehydro and deacetyl groups

Stereochemistry

Features an epimeric carbon at the C7 position

Biological activity

Exhibits significant biological activity

Intermediate

Serves as a valuable intermediate in the production of paclitaxel

Chemotherapy agent

Paclitaxel, synthesized from 10-dehydro 10-deacetyl 7-epibaccatin V, is a widely used chemotherapy agent

Cancer treatment

Paclitaxel is used for the treatment of various cancers, including ovarian, breast, and lung cancer

Importance

The intricate structure and biological activity of 10-dehydro 10-deacetyl 7-epibaccatin V make it a crucial component in the development of life-saving cancer treatments.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 651293-82-2 7,13-bis(triethylsilyl)-10-dehydro-10-deacetylbaccatin III 
• 943239-53-0 C₄₁H₆₆O₁₀Si₂ 
• 943239-54-1 C₄₃H₆₈O₁₁Si₂ 
• 1051405-92-5 C₃₁H₄₀O₁₁ 
• 1051405-95-8 C₃₄H₄₂O₁₁ 
• 1051405-47-0 C₄₆H₆₃NO₁₅ 
• 1029600-32-5 SY₅₈₆-170.1 
• 1269040-70-1 SY₆₃₄-55P₁c 
• 1269040-71-2 SY₆₃₄-55P₂c 
• 1269040-73-4 SY₆₃₄-58P₁ 
• 1269040-76-7 SY₆₃₄-58P₂ 
• 1269040-78-9 SY₆₃₄-69P₁ 
• 1269040-79-0 C₄₅H₆₁NO₁₆ 
• 1269040-80-3 SY₆₃₄-70AP₁ 

Relevant articles and documents

TAXANE AND ABEO-TAXANE ANALOGS

The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.

TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.