930272-56-3

Basic information

• Product Name: tert-butyl ((5-methylpyrimidin-2-yl)methyl)carbamate
• Synonyms: tert-butyl ((5-methylpyrimidin-2-yl)methyl)carbamate
• CAS NO: 930272-56-3
• Molecular Formula: C11H17N3O2
• Molecular Weight: 223.27158
• Mol File: 930272-56-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl ((5-methylpyrimidin-2-yl)methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((5-methylpyrimidin-2-yl)methyl)carbamate(930272-56-3)
• EPA Substance Registry System: tert-butyl ((5-methylpyrimidin-2-yl)methyl)carbamate(930272-56-3)

Safety Data

• Hazardous Substances Data: 930272-56-3(Hazardous Substances Data)

Upstream product

• 251294-65-2 tert-butoxycarbonylaminomethyl-amidine 
• 42588-57-8 3-ethoxymethacrolein 
• 930272-60-9 (5-methylpyrimidin-2-yl)methanamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 38275-57-9 5-bromopyrimidine-2-carbonitrile 
• 38275-54-6 5-methylpyrimidine-2-carbonitrile 
• 19125-76-9 3-dimethylamino-2-methyl-acrylaldehyde 
• 85363-04-8 tert-butyl cyanomethylcarbamate 
• 30989-81-2 3-amino-2-methyl acrolein 

Downstream Products

• 930272-60-9 (5-methylpyrimidin-2-yl)methanamine 

Relevant articles and documents

Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds

Described are deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds of structural Formula (I), which are agonists of 5-hydroxytryptamine receptors. Also described are pharmaceutical compositions comprising the deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds, and methods of use thereof.

High-efficacy 5-HT1A agonists for antidepressant treatment: A renewed opportunity

We report the discovery of novel 5-HT1A receptor agonists and describe the process that led to the antidepressant candidate 9 (F 15599). 9 has nanomolar affinity for 5-HT1A binding sites and is over 1000-fold selective with respect to the other 5-HT1 receptor subtypes, 5-HT2-7 receptor families, and also numerous GPCRs, transporters, ion channels, and enzymes. In a cellular model of signal transduction, 9 activates h5-HT1A receptors with an efficacy superior to that of the prototypical 5-HT1A agonist (±)-8-OH-DPAT and comparators undergoing clinical trials. After acute oral administration in rats, 9 totally reverses immobility in the forced swimming test and produces behaviors characteristic of 5-HT1A receptor activation. However, these effects occurred at widely separated doses, suggesting that 9 discriminates between distinct populations of 5-HT1A receptors. While the clinical relevance of these observations is still unknown, this opens new perspectives for the treatment of depressive disorders.