932226-24-9

Basic information

• Product Name: 2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde
• Synonyms: 2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde;2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]pyrrole-3-carbaldehyde
• CAS NO: 932226-24-9
• Molecular Formula: C₁₄H₁₂F₃NO
• Molecular Weight: 267.249
• Mol File: 932226-24-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.556 °C at 760 mmHg
• Flash Point: 168.23 °C
• Appearance: /
• Density: 1.20
• CAS DataBase Reference: 2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(932226-24-9)
• EPA Substance Registry System: 2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(932226-24-9)

Safety Data

• Hazardous Substances Data: 932226-24-9(Hazardous Substances Data)

Usage

General Description

2,5-dimethyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde is a chemical compound with a complex structure that includes a pyrrole ring, a trifluoromethylphenyl group, and a carbaldehyde functional group. It is commonly used in organic synthesis and medicinal chemistry as a starting material for the preparation of various heterocyclic compounds and pharmaceuticals. The compound's unique structure and functional groups make it a valuable building block for the development of new drugs and materials with potential biological and industrial applications. Additionally, its trifluoromethyl group makes it a valuable tool in the study of fluorine chemistry and the development of fluorinated organic molecules with unique properties.

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 571-66-4 2,5-dimethyl-1-(2-(trifluoromethyl)phenyl)-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1445610-37-6 C₂₁H₁₉F₃N₂O₃ 
• 1428184-13-7 C₂₂H₂₃F₃N₂O₃ 
• 1428184-12-6 C₂₃H₂₃F₃N₂O₃ 
• 1428184-11-5 C₂₄H₂₇F₃N₄O₂ 
• 1428184-10-4 C₂₆H₃₁F₃N₄O₂ 
• 1428184-09-1 C₂₂H₂₂F₃N₃O₃ 
• 1428184-08-0 C₂₄H₂₆F₃N₃O₃ 
• 1428184-07-9 C₂₄H₂₄F₃N₃O₃ 
• 1428184-06-8 C₂₅H₂₆F₃N₃O₂ 
• 1428184-05-7 C₂₁H₂₀F₃N₃O₂ 
• 1428184-04-6 C₂₀H₁₈F₃N₃O₂ 
• 1428184-02-4 C₂₀H₁₇F₃N₂O₃ 
• 1428184-03-5 C₁₉H₁₇F₃N₂O 
• 1428184-01-3 C₂₇H₂₃F₃N₂O₃ 

Relevant articles and documents

Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria

A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid.

Discovery and optimisation studies of antimalarial phenotypic hits

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the physicochemical properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09e29 mM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds.