93315-38-9

Basic information

• Product Name: 3-Acetyl-1-benzyl-1H-indole
• Synonyms: 3-Acetyl-1-benzyl-1H-indole;1-[1-(Phenylmethyl)-1H-indol-3-yl]ethanone;1-[1-(benzyl)indol-3-yl]ethanone;1-[1-(phenylmethyl)-3-indolyl]ethanone;1-[1-(phenylmethyl)indol-3-yl]ethanone
• CAS NO: 93315-38-9
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.3071
• Mol File: 93315-38-9.mol
• Article Data: 34

Chemical Properties

• Melting Point: 109-110℃
• Boiling Point: 440.8°Cat760mmHg
• Flash Point: 220.4°C
• Appearance: /
• Density: 1.09
• Vapor Pressure: 5.71E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 3-Acetyl-1-benzyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-1-benzyl-1H-indole(93315-38-9)
• EPA Substance Registry System: 3-Acetyl-1-benzyl-1H-indole(93315-38-9)

Safety Data

• Hazardous Substances Data: 93315-38-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H15NO/c1-13(19)16-12-18(11-14-7-3-2-4-8-14)17-10-6-5-9-15(16)17/h2-10,12H,11H2,1H3

Upstream product

• 703-80-0 3-acetylindole 
• 100-39-0 benzyl bromide 
• 3376-40-7 N-benzyl-N-phenylhydroxylamine 
• 1423-60-5 methyl ethynyl ketone 
• 99532-45-3 3-acetyl-1-benzenesulfonylindole 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 20356-45-0 3-(1H-indol-3-yl)-3-oxo-propionitrile 
• 3377-71-7 N-benzylindole 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 75-36-5 acetyl chloride 
• 141-78-6 ethyl acetate 
• 120-72-9 indole 
• 390432-45-8 4-[N-benzyl-N-(2-iodophenyl)amino]-2-butanone 

Downstream Products

• 1215411-25-8 1-(1-benzylindol-3-yl)ethanol 
• 1393718-27-8 C₁₉H₁₅N₃O₂ 
• 1393718-29-0 methyl 5-(1-benzyl-1H-indol-3-yl)-1H-pyrazole-3-carboxylate 
• 1027249-34-8 C₂₀H₁₇NO₄ 
• 1169700-47-3 4-(1-benzyl-1H-indol-3-yl)-6-phenylpyrimid-2-yl-amine 
• 1616477-47-4 1-(1-benzyl-1H-indol-3-yl)-1-phenylethanol 
• 108977-91-9 2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide 

Relevant articles and documents

Synthesis of tetrahydroindolones and tetrahydrocarbazolones via palladium catalyzed C–H activation

The treatment of bromo homoallyl pyrrolyl/indolyl ketone derivatives with Pd(OAc)2 in the presence of PPh3 and Cs2CO3 in DMF resulted in the formation of tetrahydroindolones and tetrahydrocarbazolones in moderate to good isolated yields.

Cascade Access to Carboline Carboxylates from Indolyl Ketoximes and Acrylates via Palladium-Catalyzed C-H Bond Alkenylation/Annulation

An efficient palladium-catalyzed C-H bond alkenylation/annulation strategy to access carboline carboxylates from indolyl ketoximes and acrylates through C-C/C-N bond formation is reported. Indolyl ketoximes not only direct ortho -olefination with acrylate

Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C?H Activation

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biological properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C?H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Additionally, a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction.