936-35-6Relevant articles and documents
Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles: Highly selective small-molecule nociceptin/orphanin FQ receptor agonists
Kolczewski, Sabine,Adam, Geo,Cesura, Andrea M.,Jenck, Fran?ois,Hennig, Michael,Oberhauser, Thomas,Poli, Sonia M.,R?ssler, Felix,R?ver, Stephan,Wichmann, Jürgen,Dautzenberg, Frank M.
, p. 255 - 264 (2007/10/03)
Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles that act as potent and selective orphanin FQ/nociceptin (N/OFQ) receptor (NOP) agonists were identified. The best compound, (+)-5a, potently inhibited 3H-N/OFQ binding to the NOP recep