937-30-4

Basic information

• Product Name: 4-Ethylacetophenone
• Synonyms: 1-(4-ETHYL-PHENYL)ETHANONE;AKOS BBS-00004394;4'-ETHYLACETOPHENONE;4-ETHYLACETOPHENONE;4-ETHYL-1-ACETYLBENZENE;ASISCHEM D29258;1-(4-ethylphenyl)-ethanon;Acetophenone, 4'-ethyl-
• CAS NO: 937-30-4
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• EINECS: 213-326-5
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Acetophenones (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;C10;Carbonyl Compounds;Ketones
• Mol File: 937-30-4.mol
• Article Data: 82

Chemical Properties

• Melting Point: −20.6 °C(lit.)
• Boiling Point: 125 °C20 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: Colorless or pale yellow liquid
• Density: 0.993 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0397mmHg at 25°C
• Refractive Index: n20/D 1.5293(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility: Not miscible or difficult to mix in water. Soluble in alcohol.
• BRN: 1906029
• CAS DataBase Reference: 4-Ethylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethylacetophenone(937-30-4)
• EPA Substance Registry System: 4-Ethylacetophenone(937-30-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 937-30-4(Hazardous Substances Data)

Usage

Description

4-Ethylacetophenone is an organic compound with the chemical formula C8H10O. It is a colorless to pale yellow liquid with a characteristic aromatic odor. It is soluble in organic solvents and slightly soluble in water. It is used as an intermediate in the synthesis of various organic compounds and has applications in different industries.

Uses

Used in Chemical Synthesis:
4-Ethylacetophenone is used as an intermediate in the production of 1,1'-p-phenylene-bis-ethanone. This reaction requires reagent air and cobalt naphthenate, and the reaction temperature is 125°C.
Used in Liquid Crystals Industry:
4-Ethylacetophenone is used as an intermediate in the synthesis of liquid crystals. Liquid crystals are widely used in various applications, including displays, sensors, and optical devices, due to their unique properties and ability to respond to external stimuli.

InChI:InChI=1/C10H12O/c1-3-9-4-6-10(7-5-9)8(2)11/h4-7H,3H2,1-2H3

Upstream product

• 105-05-5 1,4-diethylbenzene 
• 10537-63-0 1-(4-vinylphenyl)ethanone 
• 201230-82-2 carbon monoxide 
• 50690-09-0 2-chloro-1-(4-ethylphenyl)ethan-1-one 
• 7446-70-0 aluminium trichloride 
• 141-78-6 ethyl acetate 
• 71-43-2 benzene 
• 557-20-0 diethylzinc 
• 132636-64-7 1-[4-(1,1-Dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yloxy)-phenyl]-ethanone 
• 77924-19-7 1-[4-(1-Phenyl-1H-tetrazol-5-yloxy)-phenyl]-ethanone 
• 4433-63-0 Ethyl boronic acid 
• 99-90-1 para-bromoacetophenone 
• 40307-11-7 1-ethyl-4-ethynylbenzene 
• 33967-18-9 1-(4-ethylphenyl)ethanol 

Downstream Products

• 85243-32-9 2,2-dipropoxy-4'-ethylacetophenone 
• 604-88-6 hexaethylbenzene 
• 228703-94-4 1,3-bis(4-ethylphenyl)-1,3-propanedione 
• 134340-54-8 3-(4,6-Dimethoxy-3-methyl-1H-indol-2-yl)-1,3-bis-(4-ethyl-phenyl)-6,8-dimethoxy-1,9-dimethyl-2,3-dihydro-1H-pyrrolo[1,2-a]indole 
• 3454-07-7 1-ethenyl-4-ethyl-benzene 
• 33967-18-9 1-(4-ethylphenyl)ethanol 
• 3245-23-6 p-ethylphenyl acetate 
• 2632-14-6 4-ethylphenacyl bromide 
• 121069-00-9 2,2-dichloro-1-(4-ethylphenyl)ethan-1-one 
• 50690-09-0 2-chloro-1-(4-ethylphenyl)ethan-1-one 
• 143278-21-1 1-(4-ethylphenyl)-2-iodoethan-1-one 
• 119003-53-1 C₁₀H₁₃⁽²⁾HO 
• 58953-15-4 <β-Chlor-vinyl>-<4-ethyl-phenyl>-keton 
• 105-05-5 1,4-diethylbenzene 

Relevant articles and documents

Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy

A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acid is developed. Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on the alkyl chain containing a β-position hydrogen. A series of acetophenone products were obtained in yields up to 75%.

Hydration of Alkynes to Ketones with an Efficient and Practical Polyoxomolybdate-based Cobalt Catalyst

Hydration of alkynes to ketones is one of the most atom economical and universal methods for the synthesis of carbonyl compounds. However, the basic reaction usually requires organic ligand catalysts or harsh reaction conditions to insert oxygen into the C≡C bond. Here, we report an inorganic ligand supported cobalt (III) catalyst, (NH4)3[CoMo6O18(OH)6], which is supported by a central cobalt (III) mononucleus and a ring-shaped pure inorganic ligand composed of six MoVIO6 octahedrons to avoid the disadvantages of expensive and unrecyclable organic ligand catalysts or noble metal catalysts. Under mild conditions, the cobalt (III) catalyst can be used for the hydration of alkynes to ketones. The catalyst is non-toxic, green, and environment friendly. The catalyst can be recycled at least six times with high activity. According to control experiments, a reasonable mechanism is provided.

One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines

A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, withee> 99%.