93856-88-3

Basic information

• Product Name: 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride
• Synonyms: 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride;3-MORPHOLINO-1-(2-THIENYL)-1-PROPANONE HYDROCHLORIDE
• CAS NO: 93856-88-3
• Molecular Formula: C₁₁H₁₅NO₂S*ClH
• Molecular Weight: 261.76824
• EINECS: 299-122-7
• Mol File: 93856-88-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 371.2oC at 760mmHg
• Flash Point: 178.3oC
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.05E-05mmHg at 25°C
• CAS DataBase Reference: 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride(93856-88-3)
• EPA Substance Registry System: 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride(93856-88-3)

Safety Data

• Hazardous Substances Data: 93856-88-3(Hazardous Substances Data)

Usage

General Description

3-Morpholino-1-(2-thienyl)propan-1-one hydrochloride is a chemical compound that is commonly used as a reagent in organic chemistry. It is a hydrochloride salt of 3-morpholino-1-(2-thienyl)propan-1-one, which is a substituted morpholine derivative. 3-morpholino-1-(2-thienyl)propan-1-one hydrochloride is mainly used as an intermediate for the synthesis of pharmaceutical products and as a building block for the preparation of other organic compounds. It is also used as a catalyst in various chemical reactions and as a starting material for the production of heterocyclic compounds. Additionally, it has potential applications in the development of new drugs and agrochemicals due to its unique chemical structure and reactivity.

InChI:InChI=1/C11H15NO2S.ClH/c13-10(11-2-1-9-15-11)3-4-12-5-7-14-8-6-12;/h1-2,9H,3-8H2;1H

Upstream product

• 110-91-8 morpholine 
• 88-15-3 2-Acetylthiophene 
• 50-00-0 formaldehyd 
• 10024-89-2 morpholin hydrochloride 
• 52853-19-7 N-(methylene)morpholinium chloride 
• 646-06-0 1,3-DIOXOLANE 

Downstream Products

• 126573-28-2 (2-Oxo-4-thiophen-2-yl-cyclohex-3-enyl)-acetic acid 

Relevant articles and documents

An efficient water-mediated synthetic route for the alkylation of heteroarenes

An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.

Evaluation of alkylating and intercalating properties of mannich bases for cytotoxic activity

A series of new "hybrid compounds", Mannich base derivatives of planar polycyclic/heterocyclic starting materials, was designed and synthesized. The structures of the compounds were confirmed by spectroscopic methods and elemental analysis. Cytotoxicity of compounds was investigated in three cancer cell lines (PC3, HeLa, and MCF7) and one non-tumoral cell line (293 HEK). We tested the DNA-intercalating capability of the molecules by ethidium bromide (EtBr) fluorescence displacement experiment. Compounds' alkylation potency was investigated via in vitro incubation test using 2-mercaptoethanol, a biomimetic nucleophile. The five of the compounds (7s, 9d, 10b, 11b, 12c) are reported for first time in the literature. Our results suggest that compound 9d has a biological activity close to the reference compound doxorubicin, an intercalating agent in clinical use.