94098-56-3

Basic information

• Product Name: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE
• Synonyms: (TRIFLUOROMETHYL)PHENYL-2-FURANCARBOXALDEHYDE;TIMTEC-BB SBB003217;AKOS BAR-1659;5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE;5-(2-TRIFLUOROMETHYL-PHENYL)-FURAN-2-CARBALDEHYDE;5-[2-(TRIFLUOROMETHYL)PHENYL]FURFURAL;ART-CHEM-BB B025392;ASISCHEM S91191
• CAS NO: 94098-56-3
• Molecular Formula: C₁₂H₇F₃O₂
• Molecular Weight: 240.18
• Product Categories: API intermediates;Aldehydes;Building Blocks;C10-C12;C12 to C20+;Carbonyl Compounds;Chemical Synthesis;Furans;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 94098-56-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 41-44 °C(lit.)
• Boiling Point: 331.7°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.314g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE(94098-56-3)
• EPA Substance Registry System: 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE(94098-56-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 94098-56-3(Hazardous Substances Data)

Usage

Description

5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE, also known as 5-[2-(Trifluoromethyl)phenyl]furfural, is an organic building block with a unique molecular structure that features a trifluoromethylphenyl group attached to a furan ring. 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE is characterized by its aldehyde functional group, which allows for a wide range of chemical reactions and applications in various industries.

Uses

Used in Pharmaceutical Industry:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE is utilized as a starting material for the production of various agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of effective and targeted products for agricultural use.
Used in Flavor and Fragrance Industry:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE is employed as a component in the creation of unique and complex fragrances and flavors. Its distinct chemical structure contributes to the development of novel scents and tastes for use in perfumes, cosmetics, and food products.
Used in Material Science:
In the field of material science, 5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE serves as a precursor for the development of advanced materials with specific properties. Its versatility in chemical reactions allows for the synthesis of materials with tailored characteristics for various applications, such as polymers, coatings, and adhesives.
Used in Research and Development:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE is also used as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studies in organic chemistry, materials science, and related fields, contributing to the advancement of scientific knowledge and the development of new technologies.

InChI:InChI=1/C12H7F3O2/c13-12(14,15)10-4-2-1-3-9(10)11-6-5-8(7-16)17-11/h1-7H

Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 98-01-1 furfural 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 54514-11-3 o-trifluoromethylbenzene diazonium chloride 

Downstream Products

• 691881-40-0 (5Z)-3-benzyl-5-{[5-(2-trifluoromethylphenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one 
• 260780-32-3 5-(5-(2-Trifluoromethylphenyl)furan-2-ylmethylene)-2-thioxodihydropyrimidine-4,6-dione 
• 1092795-53-3 2-{ [5-(2-(trifluoromethyl)phenyl) furan-2-yl]methyleneamino}phenol 
• 849336-08-9 2-((5-(2-(trifluoromethyl)phenyl)furan-2-yl)methylene)hydrazinecarboximidamide hydrochloride 
• 1428183-92-9 C₂₀H₁₆F₃NO₄ 
• 1619995-05-9 9,9-dimethyl-12-[5-(2-trifluoromethylphenyl)-furan-2-yl]-7,8,9,10-tetrahydrobenzo[a]acridin-11(12H)-one 
• 1619995-16-2 (E)-N-[5-(2-trifluoromethylphenyl)furan-2-ylmethylidene]naphthalen-2-amine 
• 92973-24-5 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid 
• 849336-09-0 2-((5-(2-(trifluoromethyl)phenyl)furan-2-yl)methylene)hydrazinecarboximidamide 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Synthesis of 12-hetaryl-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin- 11(12H)-ones

Three-component condensation of naphthalen-2-amine with 5-arylfuran(thiophene, N-methylpyrrole)-2-carbaldehyde and 5,5- dimethylcyclohexane-1,3-dione, as well as condensation of N-[(5- arylfuran(thiophen)-2-ylmethylidene]naphthalen-2-amine with 5,5- dimethylcyclohexane-1,3-dione gave the corresponding 12-[5-arylfuran(thiophen, N-methylpyrrol)-2-yl]-7,8,9,10-tetradrobenzo[a]acridin-11(12H)-ones.

Low catalyst loading ligand-free palladium-catalyzed direct arylation of furans: An economically and environmentally attractive access to 5-arylfurans

The direct 5-arylation of furans at very low catalyst loading using Pd(OAc)2 as catalyst without added ligand proceed in high yields. Turnover numbers up to 10000 have been obtained for the coupling of several activated aryl bromides. A wide ra