941670-63-9

Basic information

• Product Name: 2-(4-fluorophenyl)-4-methylquinoline
• Synonyms: 2-(4-fluorophenyl)-4-methylquinoline
• CAS NO: 941670-63-9
• Molecular Weight: 237.276
• Mol File: 941670-63-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-4-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-4-methylquinoline(941670-63-9)
• EPA Substance Registry System: 2-(4-fluorophenyl)-4-methylquinoline(941670-63-9)

Safety Data

• Hazardous Substances Data: 941670-63-9(Hazardous Substances Data)

Upstream product

• 371-14-2 4-fluorophenylhydrazine 
• 74845-00-4 (E)-3-(2-aminobenzene)-2-butenenitrile 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1433772-22-5 N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 551-93-9 2-aminoacetophenone 
• 4053-40-1 4-methylquinoline 1-oxide 
• 1765-93-1 4-fluoroboronic acid 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 456-22-4 4-Fluorobenzoic acid 
• 67-56-1 methanol 
• 323-91-1 2-(4-fluoro-phenyl)-quinoline 
• 459-57-4 4-fluorobenzaldehyde 
• 98-95-3 nitrobenzene 
• 108-22-5 Isopropenyl acetate 

Relevant articles and documents

The synthesis of quinolines: via denitrogenative palladium-catalyzed cascade reaction of o -aminocinnamonitriles with arylhydrazines

The first example of the palladium-catalyzed cascade reaction of o-aminocinnamonitriles with arylhydrazines has been achieved, providing an efficient synthetic pathway to access quinolines with moderate to good yields. Preliminary mechanistic experiments

Direct arylation for the synthesis of 2-arylquinolines from N-methoxyquinoline-1-ium tetrafluoroborate salts and arylboronic acids

A rapid and direct arylation reaction of N-methoxyquinoline-1-ium tetrafluoroborate derivatives and arylboronic acids with high regioselectivety at room temperature was discovered. The reaction shows exceptional functional group tolerance and broad substrate scope regarding both the quinoline derivatives and the arylboronic acids.

Simple and Clean Photo-induced Methylation of Heteroarenes with MeOH

Heteroarene methylation utilizing a cheap and safe methylation source without involving transition metals represents an important yet challenging objective. Here, a simple and clean catalyst-free protocol for the methylation of various heteroarenes (including six- and five-membered types) is described under light irradiation. This protocol employs cheap, readily available, and abundant MeOH as both the solvent and the methylation source. It was found that adding dichloromethane (DCM) as a co-solvent could significantly increase the yield of the methylation products. Heteroarenes bearing various functional groups could be methylated and tri-deuteromethylated successfully. Deuterium labeling studies suggested that the newly generated methyl group in the products consisted of two hydrogens from the methyl group and one hydrogen from the OH group in MeOH.