74845-00-4

Basic information

• Product Name: (E)-3-(2-aminobenzene)-2-butenenitrile
• Synonyms: (E)-3-(2-aminobenzene)-2-butenenitrile
• CAS NO: 74845-00-4
• Molecular Weight: 158.203
• Mol File: 74845-00-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-aminobenzene)-2-butenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-aminobenzene)-2-butenenitrile(74845-00-4)
• EPA Substance Registry System: (E)-3-(2-aminobenzene)-2-butenenitrile(74845-00-4)

Safety Data

• Hazardous Substances Data: 74845-00-4(Hazardous Substances Data)

Upstream product

• 577-59-3 2-acetylnitrobenzene 
• 80334-76-5 (E)-3-(2-nitrophenyl)but-2-enenitrile 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 863487-46-1 4-methyl-2-(4-(trifluoromethyl)phenyl)-4-methylquinoline 
• 14444-95-2 2-(4-bromophenyl)-4-methylquinoline 
• 941670-63-9 2-(4-fluorophenyl)-4-methylquinoline 
• 1039775-39-7 4-methyl-2-(m-tolyl)quinoline 
• 4789-76-8 4-methyl-2-phenylquinoline 
• 86332-76-5 C₁₄H₁₄ClN₃O₂ 
• 74845-03-7 (E)-3-(2-Azido-5-methyl-phenyl)-but-2-enenitrile 
• 80334-77-6 E-3(o-hydroxyphenyl)but-2-enonitrile 
• 13006-59-2 3-methyl-1H-indole-2-carbonitrile 

Relevant articles and documents

PREPARATION OF CINNOLINE-3,4-DICARBONITRILE AND -DICARBOXYLIC ACID

Attempts to prepare cinnoline-3,4-dicarboxylic acid from 3,4-dimethylcinnoline failed owing to the unreactivity of the 3-Me group.Successive treatment of 3-bromo-4-chlorocinnoline with sodium toluene-p-sulphinate and potassium cyanide in dimethylformamide (DMF) gave 4-toluene-p-sulphonylcinnoline-3-carbonitrile and then cinnoline-3,4-dicarbonitrile (82percent).Hydrolysis yielded cinnoline-3,4-dicarboxylic acid (53percent).Cinnoline-3,4-dicarbonitrile undergoes nucleophylic displacement of either the 4- or the 3-cyano group by ammonia or amine to give 4-amino- and 4-benzylaminocinnoline-3-carbonitrile but 3-dimethylamino-cinnoline-4-carbonitrile.